Evidence map›Paper›PMID 18971119›Full record

ReviewBest practice & research. Clinical endocrinology & metabolism2008

Exogenous and endogenous hormones and breast cancer.

Wendy Y Chen

Abstract readReview
In one paragraph

Review in Best practice & research. Clinical endocrinology & metabolism, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 95 citations in OpenAlex.

  1. Breast cancer and persistent organic pollutants (excluding DDT): a systematic literature review.Environmental science and pollution research international · 2016
    Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Genetics research · 2025
    Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Photodynamic Therapy Induced Cell Death Mechanisms in Breast Cancer.International journal of molecular sciences · 2021
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Wendy Y ChenChanning Laboratory, Brigham and Women's Hospital, 181 Longwood Avenue, Harvard Medical School, Boston, MA 02115, USA. wendy.chen@channing.harvard.edu
Brigham and Women's Hospital · US

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8M
Cardiovascular Risk Factors and Lifestyle Modification in Breast Cancer SurvivorsR03CA132575 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHEN, WENDY Y, REXRODE, KATHRYN M · 2008 to 2009
$175k
NCI NIH HHS P01 CA087969NCI NIH HHS R03 CA132575
6 · The paper itself

Abstract

Exposure to higher levels of both exogenous and endogenous hormone is associated with breast cancer risk. Because of the association between breast cancer and HRT, only the minimal duration of HRT use is recommended for symptom control, and it is not recommended for chronic disease management. Current research issues include the role of progestins, other types of HRT, duration of unopposed estrogen use, and characteristics of cancers that develop on HRT. Circulating sex steroid levels are associated with breast cancer risk, but multiple issues need to be addressed before they are used routinely in clinical practice. Current research issues include measurement of levels for routine clinical practice, integration with standard breast cancer risk models and genetic polymorphism data, and applicability to estrogen-receptor-negative cancers.

Indexed as

Breast NeoplasmsEstrogensFemaleGonadal Steroid HormonesHormone Replacement TherapyHumansEstrogensGonadal Steroid Hormones

Identifiers

PMID18971119
PMCPMC2599924
OpenAlexW1968201285

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.