ReviewTrends in microbiology2008
Relevance of studying T cell responses in SIV-infected rhesus macaques.
Review in Trends in microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Review
- Tissue-Specific DNA Methylation Changes in CD8Viruses · 2024Article
- TLR-9 agonist and CD40-targeting vaccination induces HIV-1 envelope-specific B cells with a diversified immunoglobulin repertoire in humanized mice.PLoS pathogens · 2020Article
- Determination of major histocompatibility class I and class II genetic composition of the Caribbean Primate Center specific pathogen-free rhesus macaque (Macaca mulatta) colony based on massively parallel sequencing.Journal of medical primatology · 2018Article
- Article
- Hepatic expression profiles in retroviral infection: relevance to drug hypersensitivity risk.Pharmacology research & perspectives · 2017Article
- Characterization of T Cells Specific for CFP-10 and ESAT-6 in Mycobacterium tuberculosis-Infected Mauritian Cynomolgus Macaques.Infection and immunity · 2017Article
- Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining.Journal of visualized experiments : JoVE · 2016Article
- Quantifying integrated SIV-DNA by repetitive-sampling Alu-gag PCR.Journal of virus eradication · 2016Article
- Immunogenicity of trimethoprim/sulfamethoxazole in a macaque model of HIV infection.Toxicology · 2016Article
- T memory stem cells and HIV: a long-term relationship.Current HIV/AIDS reports · 2015Review
- A more consistent intraluminal rhesus monkey model of ischemic stroke.Neural regeneration research · 2014Article
- Haplessly hoping: macaque major histocompatibility complex made easy.ILAR journal · 2013Review
- Acute neuronal injury and blood genomic profiles in a nonhuman primate model for ischemic stroke.Comparative medicine · 2012Article
- HIV and HLA class I: an evolving relationship.Immunity · 2012Review
- New paradigms for HIV/AIDS vaccine development.Annual review of medicine · 2012Review
- Morphine potentiates neurodegenerative effects of HIV-1 Tat through actions at μ-opioid receptor-expressing glia.Brain : a journal of neurology · 2011Article
- Characterization of single-nucleotide variation in Indian-origin rhesus macaques (Macaca mulatta).BMC genomics · 2011Article
- Protective efficacy of serially up-ranked subdominant CD8+ T cell epitopes against virus challenges.PLoS pathogens · 2011Article
- CD8+ T cell recognition of cryptic epitopes is a ubiquitous feature of AIDS virus infection.Journal of virology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
HIV infection, once established, is never cleared. Rare individuals do, however, control viral replication to low levels. These successful immune responses are primarily linked to certain class I MHC alleles (MHC-I). Because of this association, many AIDS vaccines in development are designed to generate virus-specific CD8+ T cells. The Merck STEP phase 2b efficacy trial of one such vaccine was recently halted, and declared a failure. Thus, basic questions regarding what constitutes an effective T cell response and how such responses could be elicited by vaccination remain open. The best animal model available to explore such issues is simian immunodeficiency virus infection of rhesus macaques, which serves as the primary proving ground for AIDS vaccines.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.