ReviewCurrent hypertension reports2008
Impaired cardiac function in leptin-deficient mice.
Review in Current hypertension reports, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 19 citations in OpenAlex.
- Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications.Physiological reviews · 2021Review
- Leptin Levels are Associated with Subclinical Cardiac Dysfunction in Obese Adolescents.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Changes in cardiac NaMolecular and cellular biochemistry · 2017Article
- Cardiovascular consequences of metabolic syndrome.Translational research : the journal of laboratory and clinical medicine · 2017Review
- Deficiency in AMP-activated protein kinase exaggerates high fat diet-induced cardiac hypertrophy and contractile dysfunction.Journal of molecular and cellular cardiology · 2011Article
- Interaction between age and obesity on cardiomyocyte contractile function: role of leptin and stress signaling.PloS one · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The obesity gene product leptin plays an important role in the physiologic regulation of appetite and energy balance. Plasma leptin levels correlate closely with body fat storage and may respond to changes in energy expenditure. Recent evidence has implicated a direct cardiac regulatory action of leptin in addition to its well-established metabolic properties. Compelling evidence has indicated a link between abnormal leptin levels (hyper- or hypoleptinemia) and cardiac dysfunction. The leptin-deficient ob/ob mice have been used as a model for insulin resistance, obesity, and type 2 diabetes. Leptin replenishment has been shown to restore the depressed cardiac contractile function in ob/ob mice, indicating a permissive role of leptin in cardiac function. The precise role of leptin or leptin deficiency on cardiac health has not been fully elucidated. This article briefly reviews leptin's physiologic role in cardiomyocyte structure and function and how leptin deficiency or disrupted signaling may trigger cardiac functional and morphologic abnormalities.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.