Evidence map›Paper›PMID 18958837›Full record

ReviewDiabetes & vascular disease research2008

Insulin therapy in acute coronary syndromes: an appraisal of completed and ongoing randomised trials with important clinical end points.

Abhinav Goyal, Kara Nerenberg, Hertzel C Gerstein, Guillermo Umpierrez, Peter W F Wilson

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Diabetes & vascular disease research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. How to manage hyperglycemia in an acute coronary syndrome patient.Current treatment options in cardiovascular medicine · 2013
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Abhinav GoyalDepartment of Epidemiology, Emory Rollins School of Public Health, Atlanta, GA, USA. agoyal4@sph.emory.edu
Kara Nerenberg
Hertzel C Gerstein
Guillermo Umpierrez
Peter W F Wilson
Hamilton Health Sciences · CAEmory and Henry College · US

Funding

Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
X LINKED NYSTAGMUS SYNDROME WITH FEATURES OF ALBINISMM01RR000039 · NCRR · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 1985 to 2007
$21.3M
NCATS NIH HHS UL1 TR000454NCRR NIH HHS M01 RR000039
6 · The paper itself

Abstract

Insulin therapy was first proposed as an adjunctive therapy in patients with acute coronary syndromes (ACS) in the 1960s. Since then, numerous randomised clinical trials have been conducted to determine the efficacy and to define the role of insulin therapy in ACS. This review will discuss: 1) completed trials of insulin therapy in ACS, including both glucose-insulin-potassium (GIK) approaches and non-GIK approaches; 2) trials of insulin therapy in critically ill non-ACS patients and the lessons from these trials that can be applied to trials of insulin in ACS patients; and 3) a summary of ongoing and planned trials of insulin in ACS patients.

Indexed as

Acute Coronary SyndromeBiomarkersBlood GlucoseCritical IllnessGlucoseHumansHyperglycemiaHypoglycemic AgentsInsulinPotassiumRandomized Controlled Trials as TopicResearch DesignTreatment OutcomeBiomarkersBlood GlucoseGlucoseglucose-insulin-potassium cardioplegic solutionHypoglycemic AgentsInsulinPotassium

Identifiers

PMID18958837
PMCPMC3746495
OpenAlexW2130815883

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.