ArticleSurgery today2008
Alpha-lipoic acid and ebselen prevent ischemia/reperfusion injury in the rat intestine.
Article in Surgery today, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- Protective Effect of Ebselen on Ischemia-reperfusion Injury in Epigastric Skin Flaps in Rats.Acta histochemica et cytochemica · 2022Article
- Alpha-Lipoic Acid Promotes Intestinal Epithelial Injury Repair by Regulating MAPK Signaling Pathways.Mediators of inflammation · 2022Article
- Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases.Frontiers in oncology · 2022Review
- The Phenolic Antioxidant 3,5-dihydroxy-4-methoxybenzyl Alcohol (DHMBA) Prevents Enterocyte Cell Death under Oxygen-Dissolving Cold Conditions through Polyphyletic Antioxidant Actions.Journal of clinical medicine · 2021Article
- Amelioration of Metal-Induced Cellular Stress by α-Lipoic Acid and Dihydrolipoic Acid through Antioxidative Effects in PC12 Cells and Caco-2 Cells.International journal of environmental research and public health · 2021Article
- Effects of Lipoic Acid on Ischemia-Reperfusion Injury.Oxidative medicine and cellular longevity · 2021Review
- Alpha lipoic acid inhibits oxidative stress-induced apoptosis by modulating of Nrf2 signalling pathway after traumatic brain injury.Journal of cellular and molecular medicine · 2019Article
- Ebselen protects rat hearts against myocardial ischemia-reperfusion injury.Experimental and therapeutic medicine · 2019Article
- A glance at black cumin (Iranian journal of basic medical sciences · 2018Review
- Alpha Lipoic Acid: A Therapeutic Strategy that Tend to Limit the Action of Free Radicals in Transplantation.International journal of molecular sciences · 2018Review
- Inhibitory mechanism against oxidative stress of caffeic acid.Journal of food and drug analysis · 2016Review
- Tramadol alleviates myocardial injury induced by acute hindlimb ischemia reperfusion in rats.Arquivos brasileiros de cardiologia · 2015Article
- α-Lipoic acid, a scavenging agent for H₂O₂, reduces ethanol-stimulated locomotion in mice.Psychopharmacology · 2012Article
- Effect of surgical stress on nuclear and mitochondrial DNA from healthy sections of colon and rectum of patients with colorectal cancer.Journal of biosciences · 2011Article
- Ketamine reduces intestinal injury and inflammatory cell infiltration after ischemia/reperfusion in rats.Surgery today · 2010Article
- Sulforaphane protects liver injury induced by intestinal ischemia reperfusion through Nrf2-ARE pathway.World journal of gastroenterology · 2010Article
- Proanthocyanidin protects intestine and remote organs against mesenteric ischemia/reperfusion injury.World journal of surgery · 2009Article
- Protective effects of thymoquinone and melatonin on intestinal ischemia-reperfusion injury.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeReactive oxygen species (ROS) and reactive nitrogen species (RNS), generated during tissue reperfusion, are characteristic of ischemia/reperfusion (I/R) injury. We conducted this study to evaluate the protective effect of alpha-lipoic acid (alpha-LA) and ebselen against intestinal I/R injury.
methodsForty Sprague-Dawley rats were divided into five groups: a sham-operated group; an I/R group, subjected to intestinal ischemia for 45 min and reperfusion for 3 days; an I/R+alpha-LA group; an I/R+ebselen group; and an I/R+alpha-LA+ebselen group. We collected ileal specimens, to measure the tissue levels of malondialdehyde (MDA), protein carbonyl content (PCC), superoxide dismutase (SOD), and glutathione peroxidase (GPx), and to evaluate the histologic changes.
resultsThere was a significant decrease in SOD and GPx levels, with an increase in MDA and PCC levels and intestinal mucosal injury in the intestinal I/R group (P<0.05). Superoxide dismutase and GPx levels were significantly higher, MDA and PCC levels were significantly lower, and intestinal injury was significantly less severe in the I/R+alpha-LA+ebselen group than in the I/R group (P<0.05). Although shortened villi and epithelial lifting were seen in the I/R group, only slight mucosal injury was seen in the treatment groups.
conclusionalpha-Lipoic acid and ebselen played an important role in attenuating I/R injury of the intestine by scavenging ROS and RNS.
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Registered trials
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