ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2009
Prevalence of virulence-associated genotypes of Helicobacter pylori and correlation with severity of gastric pathology in patients from western Sicily, Italy.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Effectiveness of eradication therapy for Helicobacter pylori infection in Africa: a systematic review and meta-analysis.BMC gastroenterology · 2023Pooled it
- Association of presence/absence and on/off patterns of Helicobacter pylori oipA gene with peptic ulcer disease and gastric cancer risks: a meta-analysis.BMC infectious diseases · 2013Pooled it
- Predicting clinical outcomes in Helicobacter pylori-positive patients using supervised learning through the integration of demographic and genomic features.BMC gastroenterology · 2026Article
- Exploring virulence factors of Helicobacter pylori isolated from gastric biopsy.Molecular biology reports · 2024Article
- Effect of the switch status of Helicobacter pylori outer inflammatory protein A on gastric diseases.AMB Express · 2023Article
- Article
- Distribution characteristics of the sabA, hofC, homA, homB and frpB-4 genes of Helicobacter pylori in different regions of China.PloS one · 2022Article
- Review
- Rapid Characterization of Virulence Determinants inJournal of clinical medicine · 2019Article
- Molecular detection ofJournal of dental sciences · 2019Article
- oipA "on" status of Helicobacter pylori is associated with gastric cancer in North-Eastern Brazil.BMC cancer · 2019Article
- Article
- Immunization with a SyntheticThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2019Article
- In Vitro Antimicrobial Activity and Downregulation of Virulence Gene Expression on Helicobacter pylori by Reuterin.Probiotics and antimicrobial proteins · 2018Article
- Low Rate ofJournal of clinical and diagnostic research : JCDR · 2017Article
- Prevalence ofBioMed research international · 2017Article
- Efficacy of Zinc Sulfate in Peptic Ulcer Disease: A Randomized Double-Blind Clinical Trial Study.Journal of clinical and diagnostic research : JCDR · 2016Article
- Prevalence of Helicobacter pylori vacA different genotypes in Isfahan, Iran.Advanced biomedical research · 2014Article
- The Role of Helicobacter pylori Outer Membrane Proteins in Adherence and Pathogenesis.Biology · 2013Article
- Molecular Basis of pathogenicity in Helicobacter pylori clinical isolates.Journal of clinical microbiology · 2010Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a bacterium like Helicobacter pylori, which is characterized by a recombinant population structure, the associated presence of genes encoding virulence factors might be considered an expression of a selective advantage conferred to strains with certain genotypes and, therefore, a potentially useful tool for predicting the clinical outcome of infections. However, differences in the geographical and ethnic prevalence of the H. pylori virulence-associated genotypes can affect their clinical predictive value and need to be considered in advance. In this study we carried out such an evaluation in a group of patients living in Sicily, the largest and most populous island in the Mediterranean Sea. cagA, vacA, babA2, hopQ, oipA, sabA, and hopZ were the H. pylori virulence-associated genes assayed; their presence, expression status or allelic homologs were detected in H. pylori DNA samples and/or isolated strains, obtained by gastric biopsy from 90 Sicilian patients with chronic gastritis, inactive (n = 37), active (n = 26), or active with peptic ulcer (n = 27). Genotypes cagA (+), vacAs1, vacAm1, babA2 (+), and hopQ I, I/II were identified in 51.8, 80.4, 35.2, 47.3, and 67.7% of the different samples respectively. Only these genotypes were associated with each other and with the active form of chronic gastritis, irrespective of the presence of a peptic ulcer. In our isolates their prevalence was more similar to values observed in the north of Italy and France than to those observed in Spain or other Mediterranean countries that are closer and climatically more similar to western Sicily.
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