ReviewPain research & management
A review of systematic reviews on pain interventions in hospitalized infants.
Review in Pain research & management. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Pain and distress outcomes in infants and children: a systematic review.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Pooled it
- Skin-to-skin care for procedural pain in neonates.The Cochrane database of systematic reviews · 2017Pooled it
- Pain care for patients with epidermolysis bullosa: best care practice guidelines.BMC medicine · 2014Guideline
- Trial of repeated analgesia with Kangaroo Mother Care (TRAKC Trial).BMC pediatrics · 2013Trial
- Stress response and procedural pain in the preterm newborn: the role of pharmacological and non-pharmacological treatments.European journal of pediatrics · 2012Trial
- Infant factors that impact the ecology of human milk secretion and composition-a report from "Breastmilk Ecology: Genesis of Infant Nutrition (BEGIN)" Working Group 3.The American journal of clinical nutrition · 2023Review
- A Qualitative Study of the Pain Experiences of Children and Their Parents at a Canadian Children's Hospital.Children (Basel, Switzerland) · 2022Article
- Assessment and Management of Pain in Preterm Infants: A Practice Update.Children (Basel, Switzerland) · 2022Review
- Procedural pain in children: a qualitative study of caregiver experiences and information needs.BMC pediatrics · 2018Article
- Improving vaccine-related pain, distress or fear in healthy children and adolescents-a systematic search of patient-focused interventions.Human vaccines & immunotherapeutics · 2018Review
- Parent experiences and information needs relating to procedural pain in children: a systematic review protocol.Systematic reviews · 2017Article
- Comparative Survey of Holding Positions for Reducing Vaccination Pain in Young Infants.Pain research & management · 2017Article
- Nurses' experiences from pain management in children in Iranian culture: A phenomenology study.Journal of education and health promotion · 2017Article
- Epidemiology and management of painful procedures in children in Canadian hospitals.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2011Article
- Strategies for the prevention and management of neonatal and infant pain.Current pain and headache reports · 2010Review
- Procedural pain management for children receiving physiotherapy.Physiotherapy Canada. Physiotherapie Canada · 2010Article
- Pain prevalence in a pediatric hospital: raising awareness during Pain Awareness Week.Pain research & managementArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHospitalized infants undergo multiple, repeated painful procedures. Despite continued efforts to prevent procedural pain and improve pain management, clinical guidelines and standards frequently do not reflect the highest quality evidence from systematic reviews.
objectiveTo critically appraise all systematic reviews on the effectiveness of procedural pain interventions in hospitalized infants.
methodsA structured review was conducted on published systematic reviews and meta-analyses of pharmacological and nonpharmacological interventions of acute procedural pain in hospitalized infants. Searches were completed in the Cochrane Database of Systematic Reviews, MEDLINE, EMBASE, CINAHL and PsycINFO. Two reviewers independently selected articles for review and rated the methodological quality of the included reviews using a validated seven-point quality assessment measure. Any discrepancies were resolved by a third reviewer.
resultsOf 1469 potential systematic reviews on interventions for painful procedures in hospitalized infants, 11 high-quality reviews were included in the analysis. Pharmacological interventions supported by research evidence included premedication for intubation, dorsal penile nerve block and EMLA (AstraZeneca Canada, Inc) for circumcision, and sucrose for single painful procedures. Non-nutritive sucking, swaddling, holding, touching, positioning, facilitative tucking, breast feeding and supplemental breast milk were nonpharmacological interventions supported for procedural pain.
conclusionThere is a growing number of high-quality reviews supporting procedural pain management in infants. Ongoing research of single, repeated and combined pharmacological and nonpharmacological interventions is required to provide the highest quality evidence to clinicians for decision-making on optimal pain management.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.