ArticleMolecular vision2008
Taurine suppresses the spread of cell death in electrically coupled RPE cells.
Article in Molecular vision, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The trial behind it
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Less Is More: The RPE Cell Culture Medium Additive THT Mildly Impairs RPE Health.Advances in experimental medicine and biology · 2025Article
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- Xentry-Gap19 inhibits Connexin43 hemichannel opening especially during hypoxic injury.Drug delivery and translational research · 2020Article
- AMetabolomics : Official journal of the Metabolomic Society · 2019Article
- Rational Basis for Nutraceuticals in the Treatment of Glaucoma.Current neuropharmacology · 2018Review
- Human retinal pigment epithelial cells prefer proline as a nutrient and transport metabolic intermediates to the retinal side.The Journal of biological chemistry · 2017Article
- Bystander effects elicited by single-cell photo-oxidative blue-light stimulation in retinal pigment epithelium cell networks.Cell death discovery · 2017Article
- Generation of high-yield insulin producing cells from human bone marrow mesenchymal stem cells.Molecular biology reports · 2014Article
- Taurine deficiency damages retinal neurones: cone photoreceptors and retinal ganglion cells.Amino acids · 2012Article
- Review: taurine: a "very essential" amino acid.Molecular vision · 2012Review
- Functional analysis of hemichannels and gap-junctional channels formed by connexins 43 and 46.Molecular vision · 2010Article
- Bile acids in treatment of ocular disease.Journal of ocular biology, diseases, and informatics · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
purposeTo determine whether taurine exerts a protective effect on retinal pigment epithelium (RPE) cells exposed to a cytotoxic agent, cytochrome C (cyC), shown previously to induce apoptosis and produce cell death in electrically coupled neighboring cells.
methodsMonolayer cultures of confluent human RPE (ARPE-19) cells, which express gap-junctional proteins, were incubated in culture medium with or without taurine. After scrape loading cyC into the cells, we assayed these cells for caspase 3 activity and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining to determine the spread of apoptosis.
resultsWe found that cyC, too large a molecule to traverse gap junctional channels, produced apoptosis in cells injured by the scrape as well as those distant from the site of the scrape, presumably by the intercellular transmission of a toxic agent through the gap junctions that couple these cells. Incubation in taurine, or the gap-junction blocker, octanol, before application of cyC, reduced significantly the fraction of cells undergoing apoptosis. Voltage clamp recordings from electrically coupled Xenopus oocytes transfected with Cx43 showed that junctional communication was unaffected by taurine.
conclusionsOur results indicate that taurine can serve to suppress cell death in RPE cells independent of any effect on gap junctions. We have considered various avenues by which taurine can exert its protective effect, but the precise mechanism involved under these experimental conditions has yet to be identified.
Indexed as
Identifiers
18958305PMC2573733W1572430246What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.