ArticlePloS one2008
A quantitative and dynamic model for plant stem cell regulation.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Biophysical modelling as a tool for advancing plant science and engineering.Frontiers in plant science · 2025Review
- Assessing the role of REM13, REM34 and REM46 during the transition to the reproductive phase in Arabidopsis thaliana.Plant molecular biology · 2023Article
- Article
- Mathematical modeling of plant cell fate transitions controlled by hormonal signals.PLoS computational biology · 2020Article
- Primary wall cellulose synthase regulates shoot apical meristem mechanics and growth.Development (Cambridge, England) · 2019Article
- The logic of the floral transition: Reverse-engineering the switch controlling the identity of lateral organs.PLoS computational biology · 2017Article
- Plasmodesmata-Mediated Cell-to-Cell Communication in the Shoot Apical Meristem: How Stem Cells Talk.Plants (Basel, Switzerland) · 2017Review
- Differential regulation of meristem size, morphology and organization by the ERECTA, CLAVATA and class III HD-ZIP pathways.Development (Cambridge, England) · 2016Article
- Modulation of Arabidopsis and monocot root architecture by CLAVATA3/EMBRYO SURROUNDING REGION 26 peptide.Journal of experimental botany · 2015Article
- The never-ending story: from pluripotency to plant developmental plasticity.Development (Cambridge, England) · 2015Review
- A Developmental Framework for Graft Formation and Vascular Reconnection in Arabidopsis thaliana.Current biology : CB · 2015Article
- Modelling hormonal response and development.Trends in plant science · 2014Review
- Modeling regulatory networks to understand plant development: small is beautiful.The Plant cell · 2012Review
- Peptides and receptors controlling root development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2012Review
- Cytokinin signaling as a positional cue for patterning the apical-basal axis of the growing Arabidopsis shoot meristem.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Noise and robustness in phyllotaxis.PLoS computational biology · 2012Article
- The role of PENNYWISE and POUND-FOOLISH in the maintenance of the shoot apical meristem in Arabidopsis.Plant physiology · 2011Article
- Computational morphodynamics of plants: integrating development over space and time.Nature reviews. Molecular cell biology · 2011Article
- Plant stem cell signaling involves ligand-dependent trafficking of the CLAVATA1 receptor kinase.Current biology : CB · 2011Article
- Models of sequestration and receptor cross-talk for explaining multiple mutants in plant stem cell regulation.BMC systems biology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants maintain pools of totipotent stem cells throughout their entire life. These stem cells are embedded within specialized tissues called meristems, which form the growing points of the organism. The shoot apical meristem of the reference plant Arabidopsis thaliana is subdivided into several distinct domains, which execute diverse biological functions, such as tissue organization, cell-proliferation and differentiation. The number of cells required for growth and organ formation changes over the course of a plants life, while the structure of the meristem remains remarkably constant. Thus, regulatory systems must be in place, which allow for an adaptation of cell proliferation within the shoot apical meristem, while maintaining the organization at the tissue level. To advance our understanding of this dynamic tissue behavior, we measured domain sizes as well as cell division rates of the shoot apical meristem under various environmental conditions, which cause adaptations in meristem size. Based on our results we developed a mathematical model to explain the observed changes by a cell pool size dependent regulation of cell proliferation and differentiation, which is able to correctly predict CLV3 and WUS over-expression phenotypes. While the model shows stem cell homeostasis under constant growth conditions, it predicts a variation in stem cell number under changing conditions. Consistent with our experimental data this behavior is correlated with variations in cell proliferation. Therefore, we investigate different signaling mechanisms, which could stabilize stem cell number despite variations in cell proliferation. Our results shed light onto the dynamic constraints of stem cell pool maintenance in the shoot apical meristem of Arabidopsis in different environmental conditions and developmental states.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.