ArticleFrontiers in systems neuroscience2007
Stars and stripes in the cerebellar cortex: a voltage sensitive dye study.
Article in Frontiers in systems neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Reconstruction and Simulation of a Scaffold Model of the Cerebellar Network.Frontiers in neuroinformatics · 2019Article
- Optical interrogation of neuronal circuitry in zebrafish using genetically encoded voltage indicators.Scientific reports · 2018Article
- Modeling the Cerebellar Microcircuit: New Strategies for a Long-Standing Issue.Frontiers in cellular neuroscience · 2016Review
- The 40-year history of modeling active dendrites in cerebellar Purkinje cells: emergence of the first single cell "community model".Frontiers in computational neuroscience · 2015Review
- Reevaluation of the beam and radial hypotheses of parallel fiber action in the cerebellar cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Probing the function of neuronal populations: combining micromirror-based optogenetic photostimulation with voltage-sensitive dye imaging.Neuroscience research · 2013Article
- The cerebellar network: revisiting the critical issues.The Journal of physiology · 2011Review
- Visual experience modulates spatio-temporal dynamics of circuit activation.Frontiers in cellular neuroscience · 2011Article
- Origin and timing of voltage-sensitive dye signals within layers of the turtle cerebellar cortex.Brain research · 2010Article
- Rebuilding cerebellar network computations from cellular neurophysiology.Frontiers in cellular neuroscience · 2010Article
- Model-founded explorations of the roles of molecular layer inhibition in regulating purkinje cell responses in cerebellar cortex: more trouble for the beam hypothesis.Frontiers in cellular neuroscience · 2010Article
- Topography and response timing of intact cerebellum stained with absorbance voltage-sensitive dye.Journal of neurophysiology · 2009Article
- Regularity, variability and bi-stability in the activity of cerebellar purkinje cells.Frontiers in cellular neuroscience · 2009Article
- Synchronization in primate cerebellar granule cell layer local field potentials: basic anisotropy and dynamic changes during active expectancy.Frontiers in cellular neuroscience · 2009Article
- The Morpho/Functional Discrepancy in the Cerebellar Cortex: Looks Alone are Deceptive.Frontiers in neuroscience · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lattice-like structure of the cerebellar cortex and its anatomical organization in two perpendicular axes provided the foundations for many theories of cerebellar function. However, the functional organization does not always match the anatomical organization. Thus direct measurement of the functional organization is central to our understanding of cerebellar processing. Here we use voltage sensitive dye imaging in the isolated cerebellar preparation to characterize the spatio-temporal organization of the climbing and mossy fiber (MF) inputs to the cerebellar cortex. Spatial and temporal parameters were used to develop reliable criteria to distinguish climbing fiber (CF) responses from MF responses. CF activation excited postsynaptic neurons along a parasagittal cortical band. These responses were composed of slow ( approximately 25 ms), monophasic depolarizing signals. Neither the duration nor the spatial distribution of CF responses were affected by inhibition. Activation of MF generated responses that were organized in radial patches, and were composed of a fast ( approximately 5 ms) depolarizing phase followed by a prolonged ( approximately 100 ms) negative wave. Application of a GABA(A) blocker eliminated the hyperpolarizing phase and prolonged the depolarizing phase, but did not affect the spatial distribution of the response, thus suggesting that it is not the inhibitory system that is responsible for the inability of the MF input to generate beams of activity that propagate along the parallel fiber system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.