ArticleFrontiers in neuroengineering2008
Diffusion modeling of ATP signaling suggests a partially regenerative mechanism underlies astrocyte intercellular calcium waves.
Article in Frontiers in neuroengineering, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Gap Junctional Versus Paracrine Signaling in the Human Lens Epithelium: Analysis Based on Multicellular Ca²⁺ Imaging and Computational Modeling.Investigative ophthalmology & visual science · 2025Article
- Mechanical Modulation, Physiological Roles, and Imaging Innovations of Intercellular Calcium Waves in Living Systems.Cancers · 2025Review
- Live imaging of paracrine signaling: Advances in visualization and tracking techniques.Cell structure and function · 2025Review
- A Microfluidic Probe Integrated Device for Spatiotemporal 3D Chemical Stimulation in Cells.Micromachines · 2020Article
- Trade-Offs between Speed, Accuracy, and Dissipation in tRNAThe journal of physical chemistry letters · 2020Article
- Transmission of Mechanical Information by Purinergic Signaling.Biophysical journal · 2019Article
- Astrocyte calcium waves propagate proximally by gap junction and distally by extracellular diffusion of ATP released from volume-regulated anion channels.Scientific reports · 2017Article
- Imaging extracellular ATP with a genetically-encoded, ratiometric fluorescent sensor.PloS one · 2017Article
- Imaging and characterization of stretch-induced ATP release from alveolar A549 cells.The Journal of physiology · 2013Article
- Neuromodulation: selected approaches and challenges.Journal of neurochemistry · 2013Review
- A positive feedback cell signaling nucleation model of astrocyte dynamics.Frontiers in neuroengineering · 2013Article
- Intercellular Ca(2+) waves: mechanisms and function.Physiological reviews · 2012Review
- The computational power of astrocyte mediated synaptic plasticity.Frontiers in computational neuroscience · 2012Article
- Article
- Mapping the spatiotemporal dynamics of calcium signaling in cellular neural networks using optical flow.Annals of biomedical engineering · 2010Article
- Amyloid β-peptide directly induces spontaneous calcium transients, delayed intercellular calcium waves and gliosis in rat cortical astrocytes.ASN neuro · 2010Article
- Spatiotemporal characteristics of calcium dynamics in astrocytes.Chaos (Woodbury, N.Y.) · 2009Article
- Calcium waves in astrocyte networks: theory and experiments.Frontiers in neuroscience · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Network signaling through astrocyte syncytiums putatively contribute to the regulation of a number of both physiological and pathophysiological processes in the mammalian central nervous system. As such, an understanding of the underlying mechanisms is critical to determining any roles played by signaling through astrocyte networks. Astrocyte signaling is primarily mediated by the propagation of intercellular calcium waves (ICW) in the sense that paracrine signaling results in measurable intracellular calcium transients. Although the molecular mechanisms are relatively well known, there is conflicting data regarding the mechanism by which the signal propagates through the network. Experimentally there is evidence for both a point source signaling model in which adenosine triphosphate (ATP) is released by an initially activated astrocyte only, and a regenerative signaling model in which downstream astrocytes release ATP. We modeled both conditions as a simple lumped parameter phenomenological diffusion model and show that the only possible mechanism that can accurately reproduce experimentally measured results is a dual signaling mechanism that incorporates elements of both proposed signaling models. Specifically, we were able to accurately simulate experimentally measured in vitroICW dynamics by assuming a point source signaling model with a downstream regenerative component. These results suggest that seemingly conflicting data in the literature are actually complimentary, and represents a highly efficient and robustly engineered signaling mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.