ArticleNature clinical practice. Endocrinology & metabolism2008
Does vitamin D3 dosing schedule influence treatment efficacy in nursing home residents with vitamin D deficiency?
Article in Nature clinical practice. Endocrinology & metabolism, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- Vitamin D supplementation for prevention of mortality in adults.The Cochrane database of systematic reviews · 2014Pooled it
- Identification of a novel PPARβ/δ/miR-21-3p axis in UV-induced skin inflammation.EMBO molecular medicine · 2016Article
Corrections and comments
- Comment on
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin D deficiency is a common problem among elderly nursing home residents. In this Practice Point commentary, I discuss the findings and limitations of a randomized, controlled trial by Chel et al. that evaluated the effect of equivalent oral doses of vitamin D(3) given as 600 IU daily, 4,200 IU weekly or 18,000 IU monthly. Regardless of the dosing schedule, oral administration of vitamin D(3) was associated with increased levels of serum 25-hydroxyvitamin D and reduced levels of parathyroid hormone in the study cohort. Daily administration of vitamin D(3) was found to be more effective than either weekly or monthly administration. The addition of calcium supplementation for a 2-week period did not appreciably augment the effects of vitamin D(3) supplementation. Here, I highlight the issues to consider when interpreting studies of vitamin D(3) supplementation, its effect on vitamin D status, and the consequences for calcium and bone metabolism.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.