ArticleMolecular psychiatry2010
Genome-wide association scan for five major dimensions of personality.
Article in Molecular psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 12 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
104 citing papers in PubMed, 12 syntheses or guidelines pooled it, 291 citations in OpenAlex.
- Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.Nature genetics · 2018Pooled it
- Meta-analysis of genome-wide SNP- and pathway-based associations for facets of neuroticism.Journal of human genetics · 2017Pooled it
- Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium.Behavior genetics · 2016Pooled it
- GWA meta-analysis of personality in Korean cohorts.Journal of human genetics · 2015Pooled it
- Genetic and environmental continuity in personality development: a meta-analysis.Psychological bulletin · 2014Pooled it
- Personality and risk of Alzheimer's disease: new data and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2014Pooled it
- Genetics of serum BDNF: meta-analysis of the Val66Met and genome-wide association study.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2013Pooled it
- Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes.European journal of human genetics : EJHG · 2012Pooled it
- Meta-analysis of genome-wide association studies for personality.Molecular psychiatry · 2012Pooled it
- Meta-analysis of genome-wide association studies identifies common variants in CTNNA2 associated with excitement-seeking.Translational psychiatry · 2011Pooled it
- Genome-wide association scan of trait depression.Biological psychiatry · 2010Pooled it
- BDNF Val66Met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Pooled it
- Personality Genomics.Annual review of psychology · 2026Review
- Multisite, Multiancestry Genome-Wide Association Study Meta-Analysis of Functional Seizure Disorder in a Hospital Sample of 675,680 Patients.Biological psychiatry global open science · 2026Article
- Linking Personality Traits to Mediterranean Diet Adherence and Exploring Gene-Diet Interactions in Neuroticism.Nutrients · 2025Article
- Missense variants in ANO4 cause sporadic encephalopathic or familial epilepsy with evidence for a dominant-negative effect.American journal of human genetics · 2024Article
- Which Came First? When Usher Syndrome Type 1 Couples with Neuropsychiatric Disorders.Audiology research · 2023Article
- Article
- Polymodal Control of TMEM16x Channels and Scramblases.International journal of molecular sciences · 2022Review
- Article
44 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 6 institutions in 3 countries.
Funding
Abstract
Personality traits are summarized by five broad dimensions with pervasive influences on major life outcomes, strong links to psychiatric disorders and clear heritable components. To identify genetic variants associated with each of the five dimensions of personality we performed a genome-wide association (GWA) scan of 3972 individuals from a genetically isolated population within Sardinia, Italy. On the basis of the analyses of 362 129 single-nucleotide polymorphisms we found several strong signals within or near genes previously implicated in psychiatric disorders. They include the association of neuroticism with SNAP25 (rs362584, P=5 x 10(-5)), extraversion with BDNF and two cadherin genes (CDH13 and CDH23; Ps<5 x 10(-5)), openness with CNTNAP2 (rs10251794, P=3 x 10(-5)), agreeableness with CLOCK (rs6832769, P=9 x 10(-6)) and conscientiousness with DYRK1A (rs2835731, P=3 x 10(-5)). Effect sizes were small (less than 1% of variance), and most failed to replicate in the follow-up independent samples (N up to 3903), though the association between agreeableness and CLOCK was supported in two of three replication samples (overall P=2 x 10(-5)). We infer that a large number of loci may influence personality traits and disorders, requiring larger sample sizes for the GWA approach to confidently identify associated genetic variants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.