ReviewMicrobiology (Reading, England)2008
A model of efficiency: stress tolerance by Streptococcus mutans.
Review in Microbiology (Reading, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 188 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
188 citing papers in PubMed, 1 synthesis or guideline pooled it, 319 citations in OpenAlex.
- A systematic review of Streptococcus Mutans and Veillonellae species interactions in dental caries progression: Positive or Negative impact?F1000Research · 2024Pooled it
- Dissecting the essential role ofVirulence · 2026Article
- Life stage shifts in salivary microbiota determinants: a cross-sectional study in twins.NPJ biofilms and microbiomes · 2026Article
- An XRE-type regulator inMicrobiology spectrum · 2026Article
- Patchouli Alcohol as a Potential Anti-Cariogenic Compound TargetingMolecules (Basel, Switzerland) · 2026Article
- Air restriction enhancesMicrobiology spectrum · 2026Article
- Acid shock triggers virulence surge accompanied by bacterial elongation in streptococcus mutans.Scientific reports · 2026Article
- Atmospheric Cold Microwave Argon Plasma for Decontamination of Dental Implant Surfaces: An In Vitro Experimental Study.Journal of functional biomaterials · 2026Article
- AJournal of bacteriology · 2026Review
- The genomic history of Streptococcus mutans from the Mesolithic until modern times.Genome biology · 2026Article
- Buprenorphine enhancesJournal of oral microbiology · 2026Article
- Strain-level genomic variation ofPeerJ · 2026Article
- Impact ofFrontiers in oral health · 2026Article
- SppR inFrontiers in cellular and infection microbiology · 2026Article
- Pyruvate metabolism is involved in adaptability and cariogenicity ofJournal of oral microbiology · 2026Review
- Design of a Novel Peptide-Based Vaccine TargetingInternational journal of dentistry · 2026Article
- Effect of cold atmospheric plasma on common oral pathogenic microorganisms: a narrative review.Annals of medicine · 2025Review
- Forging biofilms: metal-induced microbial responses in biofilm formation.Journal of bacteriology · 2025Review
- Role ofMicroorganisms · 2025Article
- Genome resequencing and comparative analysis of Streptococcus mutans in adults with high and low caries risk.Scientific data · 2025Article
128 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The complete genome sequence of Streptococcus mutans, a bacterial pathogen commonly associated with human dental caries, was published in 2002. The streamlined genome (2.03 Mb) revealed an organism that is well adapted to its obligately host-associated existence in multispecies biofilms on tooth surfaces: a dynamic environment that undergoes rapid and substantial fluctuations. However, S. mutans lacks many of the sensing systems and alternative sigma factors that bacteria often use to coordinate gene expression in response to stress and changes in their environment. Over the past 7 years, functional genomics and proteomics have enhanced our understanding of how S. mutans has integrated the stress regulon and global transcriptional regulators to coordinate responses to environmental fluctuations with modulation of virulence in a way that ensures persistence in the oral cavity and capitalizes on conditions that are favourable for the development of dental caries. Here, we highlight advances in dissection of the stress regulon of S. mutans and its intimate interrelationship with pathogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.