ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2009
Review. The mammalian proton-coupled peptide cotransporter PepT1: sitting on the transporter-channel fence?
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Bioactive Collagen Peptides in Veterinary and Biomedical Science-Part I: Molecular Identity, Gastrointestinal Bioavailability, and Receptor-Mediated Signaling, with Relevance to the Bile Acid Axis.Veterinary sciences · 2026Review
- The Expression Characteristics of NPF Genes and Their Response to Vernalization and Nitrogen Deficiency in Rapeseed.International journal of molecular sciences · 2021Article
- Aromatic dipeptide Trp-Ala can be transported by Arabidopsis peptide transporters AtPTR1 and AtPTR5.Channels (Austin, Tex.) · 2017Article
- Di- and tripeptide transport in vertebrates: the contribution of teleost fish models.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Review
- Molecular identification and functional characteristics of peptide transporters in the bonnethead shark (Sphyrna tiburo).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Article
- USP18 Sensitivity of Peptide Transporters PEPT1 and PEPT2.PloS one · 2015Article
- Teleost fish models in membrane transport research: the PEPT1(SLC15A1) H+-oligopeptide transporter as a case study.The Journal of physiology · 2014Review
- Effect of Janus kinase 3 on the peptide transporters PEPT1 and PEPT2.The Journal of membrane biology · 2013Article
- ACE2 - from the renin-angiotensin system to gut microbiota and malnutrition.Microbes and infection · 2013Review
- Peptide transporter DtpA has two alternate conformations, one of which is promoted by inhibitor binding.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Pathogenesis of human enterovirulent bacteria: lessons from cultured, fully differentiated human colon cancer cell lines.Microbiology and molecular biology reviews : MMBR · 2013Review
- Functional and structural determinants of reverse operation in the pH-dependent oligopeptide transporter PepT1.Cellular and molecular life sciences : CMLS · 2011Article
- Assimilation of water and dietary ions by the gastrointestinal tract during digestion in seawater-acclimated rainbow trout.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2011Article
- Residues R282 and D341 act as electrostatic gates in the proton-dependent oligopeptide transporter PepT1.The Journal of physiology · 2011Article
- Functional role of the intracellular loop linking transmembrane domains 6 and 7 of the human dipeptide transporter hPEPT1.The Journal of membrane biology · 2010Article
- Drug transporter, P-glycoprotein (MDR1), is an integrated component of the mammalian blood-testis barrier.The international journal of biochemistry & cell biology · 2009Article
- Introduction. The blurred boundary between channels and transporters.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The proton-coupled di- and tripeptide transporter PepT1 (SLC15a1) is the major route by which dietary nitrogen is taken up from the small intestine, as well as being the route of entry for important therapeutic (pro)drugs such as the beta-lactam antibiotics, angiotensin-converting enzyme inhibitors and antiviral and anti-cancer agents. PepT1 is a member of the major facilitator superfamily of 12 transmembrane domain transporter proteins. Expression studies in Xenopus laevis on rabbit PepT1 that had undergone site-directed mutagenesis of a conserved arginine residue (arginine282 in transmembrane domain 7) to a glutamate revealed that this residue played a role in the coupling of proton and peptide transport and prevented the movement of non-coupled ions during the transporter cycle. Mutations of arginine282 to other non-positive residues did not uncouple proton-peptide cotransport, but did allow additional ion movements when substrate was added. By contrast, mutations to positive residues appeared to function the same as wild-type. These findings are discussed in relation to the functional role that arginine282 may play in the way PepT1 operates, together with structural information from the homology model of PepT1 based on the Escherichia coli lactose permease crystal structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.