ArticleNeuron2008
The neural substrate of spectral preference in Drosophila.
Article in Neuron, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 180 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
180 citing papers in PubMed, 315 citations in OpenAlex.
- Sensory receptor expansion and neural accommodation in butterfly color vision.Science advances · 2026Article
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- Robust Detection of Small Moving Objects Against Real-World Complex Dynamic Natural Environments: Drosophila-Inspired Visual Neural Pathway Modeling.Biomimetics (Basel, Switzerland) · 2026Article
- A day sleep promoting role of phototransduction inNeurobiology of sleep and circadian rhythms · 2026Article
- Homotypic dendritic interactions constrain growth and receptor distribution in Drosophila T4 neurons without affecting orientation or function.Development (Cambridge, England) · 2026Article
- Conflicting adaptations in an inhibitory feedback circuit.The Journal of physiology · 2026Article
- Imprecision in Vision: Lessons From Neural Circuits in the Fly.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Article
- Two classes of amine/glutamate multi-transmitter neurons innervate Drosophila internal male reproductive organs.bioRxiv : the preprint server for biology · 2025Article
- Sensory receptor expansion and neural accommodation in butterfly color vision.bioRxiv : the preprint server for biology · 2025Article
- Innate spectral preferences and aversive visual learning reveal wavelength-dependent preferences and discrimination in Drosophila melanogaster.Scientific reports · 2025Article
- Article
- Oviposition Response to Light With Different Spectra in the Crepuscular MothEcology and evolution · 2025Article
- Article
- Single-cell type analysis of wing premotor circuits in the ventral nerve cord ofbioRxiv : the preprint server for biology · 2025Article
- A recurrent neural circuit in Drosophila temporally sharpens visual inputs.Current biology : CB · 2025Article
- Rapid lightsheet fluorescence imaging of whole Drosophila brains at nanoscale resolution by potassium acrylate-based expansion microscopy.Nature communications · 2024Article
- Advances in the labelling and selective manipulation of synapses.Nature reviews. Neuroscience · 2024Review
- Article
- Drosophila require both green and UV wavelengths for sun orientation but lack a time-compensated sun compass.The Journal of experimental biology · 2024Article
120 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 6 institutions in 3 countries.
Funding
Abstract
Drosophila vision is mediated by inputs from three types of photoreceptor neurons; R1-R6 mediate achromatic motion detection, while R7 and R8 constitute two chromatic channels. Neural circuits for processing chromatic information are not known. Here, we identified the first-order interneurons downstream of the chromatic channels. Serial EM revealed that small-field projection neurons Tm5 and Tm9 receive direct synaptic input from R7 and R8, respectively, and indirect input from R1-R6, qualifying them to function as color-opponent neurons. Wide-field Dm8 amacrine neurons receive input from 13-16 UV-sensing R7s and provide output to projection neurons. Using a combinatorial expression system to manipulate activity in different neuron subtypes, we determined that Dm8 neurons are necessary and sufficient for flies to exhibit phototaxis toward ultraviolet instead of green light. We propose that Dm8 sacrifices spatial resolution for sensitivity by relaying signals from multiple R7s to projection neurons, which then provide output to higher visual centers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.