ArticleNeuron2008
Dendritic NMDA receptors activate axonal calcium channels.
Article in Neuron, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 92 citations in OpenAlex.
- Bidirectional control of vesicular GABA release, LTP, and amotivation by GluN2D-selective allosteric modulators and ketamine.Cell reports · 2026Article
- NMDA and glycine receptors provide dual presynaptic regulation on climbing fibre inputs to cerebellar Purkinje cells.The Journal of physiology · 2026Article
- Article
- GluN2A- and GluN2B-containing pre-synapticPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Direct and indirect pathways for heterosynaptic interaction underlying developmental synapse elimination in the mouse cerebellum.Communications biology · 2024Article
- Presynaptic NMDA Receptors Influence CaNeural plasticity · 2022Article
- Synaptic NMDA receptor activity at resting membrane potentials.Frontiers in cellular neuroscience · 2022Article
- Article
- Neuropilin 2 Signaling Mediates Corticostriatal Transmission, Spine Maintenance, and Goal-Directed Learning in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Interneuronal NMDA receptors regulate long-term depression and motor learning in the cerebellum.The Journal of physiology · 2019Article
- NMDA receptor-dependent presynaptic inhibition at the calyx of Held synapse of rat pups.Open biology · 2017Article
- Rapid State-Dependent Alteration in KCell reports · 2017Article
- Granular Layer Neurons Control Cerebellar Neurovascular Coupling Through an NMDA Receptor/NO-Dependent System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Postsynaptic, not presynaptic NMDA receptors are required for spike-timing-dependent LTD induction.Nature neuroscience · 2016Article
- Neuroligins Are Selectively Essential for NMDAR Signaling in Cerebellar Stellate Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Excitation by Axon Terminal GABA Spillover in a Sound Localization Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Presynaptic GluN2D receptors detect glutamate spillover and regulate cerebellar GABA release.Journal of neurophysiology · 2016Article
- Roles of Presynaptic NMDA Receptors in Neurotransmission and Plasticity.Trends in neurosciences · 2016Review
- Presynaptic NMDA receptors - dynamics and distribution in developing axons in vitro and in vivo.Journal of cell science · 2015Article
- Properties and molecular identity of NMDA receptors at synaptic and non-synaptic inputs in cerebellar molecular layer interneurons.Frontiers in synaptic neuroscience · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
NMDA receptor (NMDAR) activation can alter synaptic strength by regulating transmitter release from a variety of neurons in the CNS. As NMDARs are permeable to Ca(2+) and monovalent cations, they could alter release directly by increasing presynaptic Ca(2+) or indirectly by axonal depolarization sufficient to activate voltage-sensitive Ca(2+) channels (VSCCs). Using two-photon microscopy to measure Ca(2+) excursions, we found that somatic depolarization or focal activation of dendritic NMDARs elicited small Ca(2+) transients in axon varicosities of cerebellar stellate cell interneurons. These axonal transients resulted from Ca(2+) entry through VSCCs that were opened by the electrotonic spread of the NMDAR-mediated depolarization elicited in the dendrites. In contrast, we were unable to detect direct activation of NMDARs on axons, indicating an exclusive somatodendritic expression of functional NMDARs. In cerebellar stellate cells, dendritic NMDAR activation masquerades as a presynaptic phenomenon and may influence Ca(2+) -dependent forms of presynaptic plasticity and release.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.