ReviewCell biology and toxicology2008
Environmental sensing and response genes in cnidaria: the chemical defensome in the sea anemone Nematostella vectensis.
Review in Cell biology and toxicology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Control of water excretion in Hydra vulgaris by neural integration.Current biology : CB · 2026Article
- Early transcription factor activation distinguishes symbiotic from non-symbiotic bacteria during microbiome processing in a sponge.The ISME journal · 2026Article
- Anthozoan Chemical Defenses: Integrating Compounds, Enzymatic Activities, and Omics-Based Discoveries.International journal of molecular sciences · 2025Review
- Hypoxia Disrupts Sex-Specific Physiology and Gene Expression Leading to Decreased Fitness in the Estuarine Sea Anemone Nematostella vectensis.Molecular ecology · 2025Article
- Understanding Dynamic Molecular Responses Is Key to Designing Environmental Stress Experiments: A Review of Gene and Protein Expression in Cnidaria Under Stress.Molecular ecology · 2025Review
- Rapid Evolution in Action: Environmental Filtering Supports Coral Adaptation to a Hot, Acidic, and Deoxygenated Extreme Habitat.Global change biology · 2025Article
- The Chemical Defensome: A Survey of Environmental Sensing and Response Genes in Copepods.International journal of molecular sciences · 2025Article
- Synergistic and antagonistic interactions of oxybenzone and ocean acidification: new insight into vulnerable cellular processes in non-calcifying anthozoans.Frontiers in physiology · 2023Article
- Article
- The chemical defensome of five model teleost fish.Scientific reports · 2021Article
- The cytochrome P450 (CYP) superfamily in cnidarians.Scientific reports · 2021Article
- Sea Anemones Responding to Sex Hormones, Oxybenzone, and Benzyl Butyl Phthalate: Transcriptional Profiling andFrontiers in genetics · 2021Article
- Dynamic remodeling of the interactomes of Nematostella vectensis Hsp70 isoforms under heat shock.Journal of proteomics · 2019Article
- Clonal diversity impacts coral cover inEcology and evolution · 2019Article
- Insecticide Exposure Triggers a Modulated Expression of ABC Transporter Genes in Larvae ofInsects · 2019Article
- Characterizing functional differences in sea anemone Hsp70 isoforms using budding yeast.Cell stress & chaperones · 2018Article
- Independent losses of a xenobiotic receptor across teleost evolution.Scientific reports · 2018Article
- Transcriptome-wide analysis of differential gene expression in response to light:dark cycles in a model cnidarian.Comparative biochemistry and physiology. Part D, Genomics & proteomics · 2018Article
- The choreography of the chemical defensome response to insecticide stress: insights into the Anopheles stephensi transcriptome using RNA-Seq.Scientific reports · 2017Article
- Different Principles of ADP-Ribose-Mediated Activation and Opposite Roles of the NUDT9 Homology Domain in the TRPM2 Orthologs of Man and Sea Anemone.Frontiers in physiology · 2017Review
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Abstract
The starlet sea anemone Nematostella vectensis has been recently established as a new model system for the study of the evolution of developmental processes, as cnidaria occupy a key evolutionary position at the base of the bilateria. Cnidaria play important roles in estuarine and reef communities, but are exposed to many environmental stressors. Here, I describe the genetic components of a "chemical defensome" in the genome of N. vectensis and review cnidarian molecular toxicology. Gene families that defend against chemical stressors and the transcription factors that regulate these genes have been termed a chemical defensome and include the cytochromes P450 and other oxidases, various conjugating enyzymes, the ATP-dependent efflux transporters, oxidative detoxification proteins, as well as various transcription factors. These genes account for about 1% (266/27,200) of the predicted genes in the sea anemone genome, similar to the proportion observed in tunicates and humans, but lower than that observed in sea urchins. While there are comparable numbers of stress-response genes, the stress sensor genes appear to be reduced in N. vectensis relative to many model protostomes and deuterostomes. Cnidarian toxicology is understudied, especially given the important ecological roles of many cnidarian species. New genomic resources should stimulate the study of chemical stress sensing and response mechanisms in cnidaria and allow us to further illuminate the evolution of chemical defense gene networks.
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