ArticleLipids2009
Alterations in the high density lipoprotein phenotype and HDL-associated enzymes in subjects with metabolic syndrome.
Article in Lipids, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 73 citations in OpenAlex.
- Effect of soy on metabolic syndrome and cardiovascular risk factors: a randomized controlled trial.European journal of nutrition · 2018Trial
- Trial
- The Effect of Theobromine Supplementation on HDL-c Subclasses (HDL-c2, HDL-c3), HDL-c2/HDL-c3 Ratio, and Gene Expression of PPAR-α and Sirt1 in Subjects With Metabolic Syndrome: A Randomized Controlled Clinical Trial.Food science & nutrition · 2025Article
- HDL-C criterion of the metabolic syndrome and future diabetes and atherosclerosis in midlife women: The SWAN Study.American journal of preventive cardiology · 2024Article
- The Association of HDL2b with Metabolic Syndrome Among Normal HDL-C Populations in Southern China.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Nonalcoholic Fatty Pancreas Disease: Role in Metabolic Syndrome, "Prediabetes," Diabetes and Atherosclerosis.Digestive diseases and sciences · 2022Review
- Review
- Lipoprotein Lipase Inhibitor, Nordihydroguaiaretic Acid, Aggravates Metabolic Phenotypes and Alters HDL Particle Size in the Western Diet-Fed db/db Mice.International journal of molecular sciences · 2019Article
- Maternal Gestational Diabetes Mellitus increases placental and foetal lipoprotein-associated Phospholipase A2 which might exert protective functions against oxidative stress.Scientific reports · 2017Article
- Subfractions of high-density lipoprotein (HDL) and dysfunctional HDL in chronic kidney disease patients.Archives of medical science : AMS · 2016Article
- HDL2/HDL3 Ratio Changes, Metabolic Syndrome Markers, and Other Factors in a Japanese Population.Journal of atherosclerosis and thrombosis · 2016Article
- High density lipoprotein and metabolic disease: Potential benefits of restoring its functional properties.Molecular metabolism · 2016Review
- Correlation Between High-Density Lipoprotein and Monocyte Subsets in Patients with Stable Coronary Heart Disease.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Amount of hepatic fat predicts cardiovascular risk independent of insulin resistance among Hispanic-American adolescents.Lipids in health and disease · 2015Article
- Correlation between high density lipoprotein and monocyte subpopulations among stable coronary atherosclerotic heart disease patients.International journal of clinical and experimental medicine · 2015Article
- Small high-density lipoprotein is associated with monocyte subsets in stable coronary artery disease.Atherosclerosis · 2014Article
- High density lipoproteins and type 2 diabetes: Emerging concepts in their relationship.World journal of experimental medicine · 2014Article
- Cholesterol forms and traditional lipid profile for projection of atherogenic dyslipidemia: lipoprotein subfractions and erythrocyte membrane cholesterol.The Journal of membrane biology · 2014Article
- Lipoprotein subfraction profile and HDL-associated enzymes in sickle cell disease patients.Lipids · 2013Article
- High density lipoprotein and cardiovascular diseases.World journal of cardiology · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with metabolic syndrome (MetS) usually have low high density lipoprotein cholesterol (HDL-C) levels. We determined the HDL distribution profile as well as the HDL-related lipoprotein associated phospholipase A(2) (HDL-LpPLA(2)) and paraoxonase-1 (PON1) activities in subjects with MetS (n = 189) but otherwise healthy. Age and sex-matched individuals (n = 166) without MetS served as controls. The lower HDL-C concentration in MetS patients was due to a reduction in both large and small HDL subclasses (P < 0.001 and P < 0.05, respectively). As the number of MetS components increased, the HDL phenotype comprised of a greater percentage of small HDL-3 and less large HDL-2 subclasses, resulting in a decreased HDL-2/HDL-3 ratio (P < 0.001 for all trends). Multivariate analysis revealed that HDL-2 levels and the HDL-2/HDL-3 ratio significantly and independently correlated with HDL-C (positively) and TG (negatively) levels. HDL-3 concentration significantly and independently positively correlated with HDL-C and TG levels. HDL-LpPLA(2) activity was decreased in MetS patients (P < 0.01), a phenomenon that may contribute to the defective antiatherogenic activity of HDL in MetS. PON1 activity did not differ between groups. We conclude that MetS, in addition to the decrease in HDL-C concentration, is associated with alterations in the HDL phenotype, which is comprised of a greater percentage of small HDL subclasses. Furthermore, HDL-LpPLA(2) activity is decreased in MetS patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.