ArticleJournal of cancer research and clinical oncology2009
Diagnosis of unknown nonhematological tumors by bone marrow biopsy: a retrospective analysis of 10,112 samples.
Article in Journal of cancer research and clinical oncology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 33 citations in OpenAlex.
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- LDH-to-Albumin Ratio (LAR) in Solid Tumor Patients with Cytopenia: A Simple Biomarker to Predict Bone Marrow Metastasis.Journal of clinical medicine · 2025Article
- Bone Marrow Metastasis in Non-hematological Malignancies: Data From a Tertiary Care Hospital in North India.Cureus · 2025Article
- Bone marrow metastasis of ovarian cancer: A two‑center retrospective study and literature review.Molecular and clinical oncology · 2025Article
- Challenges and Clinical Relevance in Diagnosing Metastatic Cells From Non-Hematopoietic Malignancies in Bone Marrow Aspirates.Cancer medicine · 2025Article
- Mechanism and clinical progression of solid tumors bone marrow metastasis.Frontiers in pharmacology · 2024Review
- Bone marrow metastatic neuroendocrine carcinoma with unknown primary site: A case report and review of the literature.World journal of clinical cases · 2022Article
- Symptomatic bone marrow metastases in breast cancer: A retrospective cohort study.Frontiers in oncology · 2022Article
- Detection of Metastatic Tumor Cells in the Bone Marrow Aspirate Smears by Artificial Intelligence (AI)-BasedFrontiers in oncology · 2021Article
- Article
- Diffuse Bone Marrow Metastasis as the Initial Presentation of an Occult Breast Cancer.Case reports in oncological medicine · 2018Article
- Long-term survival after a favorable response to anti-EGFR antibody plus chemotherapy to treat bone marrow metastasis: a case report ofOncoTargets and therapy · 2017Article
- Bone marrow metastasis in primary bronchial mucoepidermoid carcinoma: a case report.World journal of surgical oncology · 2014Article
- Clustered precursors in bone marrow sections predict early relapse in patients with acute myeloid leukemia within hematologic remission.Journal of translational medicine · 2014Article
- Bone marrow metastasis in nonhematological malignancies: A study from tertiary care center.Annals of African medicineArticle
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6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate how unselected bone marrow (BM) biopsy examinations could help in the diagnosis of clinically unknown nonhematological tumors.
methods10,112 plastic-embedded BM biopsy sections were retrospectively analyzed. In the analysis we focused on the following aspects: (1) the frequency of BM involvement arising from clinically unknown nonhematological malignancies, (2) the clinical indication for BM biopsy examination in cases with tumor BM metastasis, (3) the primary sites of the metastatic tumors, and (4) the advantage of plastic-embedded biopsy sections over paraffin-embedded samples and the complementarity of biopsy with aspiration smears.
resultsOf the 10,112 BM samples analyzed, 101 (1.0%) were interpreted as being nonhematological tumor metastases. In cases with metastatic tumors, the nonhemocyte-related changes, such as skeletal pain (25%) and bone destruction (5%), were considerably higher than in those without metastasis (3.7 and 0.32%, respectively; P < 0.001). Primary lesions were documented antemortem in 50 of the 101 biopsy-positive cases (49.5%); the most frequent being in the lung, gastric tract, and breast. Using this assay, a higher incidence of metastatic tumors was detected when compared with previously reported paraffin-embedded samples. The frequency of metastatic tumors based on aspiration smears when the positive results for biopsy sections were used as a reference was 74.3%. All the 101 sections with metastatic tumors showed various degrees of myelofibrosis.
conclusionsWe concluded that the routine BM biopsy examination is helpful in detecting insidious metastatic nonhematological malignancies. Skeletal pain and bone destruction are critical indications for susceptible patients to undergo BM examination. Plastic embedding of biopsy sections appears to be more sensitive than the paraffin embedding of samples and is an excellent complementation to isolated aspiration smears.
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