ArticleImmunogenetics2008
Comparative genetics of a highly divergent DRB microsatellite in different macaque species.
Article in Immunogenetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Genetic Conservation and Population Management of Non-Human Primates: Parentage Determination Using Seven Microsatellite-Based Multiplexes.Ecology and evolution · 2025Article
- Dynamic evolution of Mhc haplotypes in cynomolgus macaques of different geographic origins.Immunogenetics · 2022Article
- Complete nucleotide sequence characterization of DRB5 alleles reveals a homogeneous allele group that is distinct from other DRB genes.Human immunology · 2019Article
- Low genetic variation in the MHC class II DRB gene and MHC-linked microsatellites in endangered island populations of the leopard cat (Prionailurus bengalensis) in Japan.Immunogenetics · 2018Article
- A quick and robust MHC typing method for free-ranging and captive primate species.Immunogenetics · 2017Article
- Characterising a microsatellite for DRB typing in Aotus vociferans and Aotus nancymaae (Platyrrhini).PloS one · 2014Article
- Haplotype diversity generated by ancient recombination-like events in the MHC of Indian rhesus macaques.Immunogenetics · 2013Article
- Large-scale MHC class II genotyping of a wild lemur population by next generation sequencing.Immunogenetics · 2012Article
- Evolution of HLA-DRB genes.Molecular biology and evolution · 2012Article
- Multilocus definition of MHC haplotypes in pedigreed cynomolgus macaques (Macaca fascicularis).Immunogenetics · 2012Article
- DR haplotype diversity of the cynomolgus macaque as defined by its transcriptome.Immunogenetics · 2012Article
- Characterization of full-length MHC class II sequences in Indonesian and Vietnamese cynomolgus macaques.Immunogenetics · 2011Article
- Genomic plasticity of the MHC class I A region in rhesus macaques: extensive haplotype diversity at the population level as revealed by microsatellites.Immunogenetics · 2011Article
- Sequence analysis of the grey mouse lemur (Microcebus murinus) MHC class II DQ and DR region.Immunogenetics · 2011Article
- Extensive DRB region diversity in cynomolgus macaques: recombination as a driving force.Immunogenetics · 2010Article
- The chimpanzee Mhc-DRB region revisited: gene content, polymorphism, pseudogenes, and transcripts.Molecular immunology · 2009Article
- Definition of Mafa-A and -B haplotypes in pedigreed cynomolgus macaques (Macaca fascicularis).Immunogenetics · 2009Article
- Evidence for balancing selection acting on KIR2DL4 genotypes in rhesus macaques of Indian origin.Immunogenetics · 2009Article
- High levels of genetic variation at MHC class II DBB loci in the tammar wallaby (Macropus eugenii).Immunogenetics · 2009Article
- Development of MHC-Linked Microsatellite Markers in the Domestic Cat and Their Use to Evaluate MHC Diversity in Domestic Cats, Cheetahs, and Gir Lions.The Journal of heredityArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The DRB region of the major histocompatibility complex (MHC) of cynomolgus and rhesus macaques is highly plastic, and extensive copy number variation together with allelic polymorphism makes it a challenging enterprise to design a typing protocol. All intact DRB genes in cynomolgus monkeys (Mafa) appear to possess a compound microsatellite, DRB-STR, in intron 2, which displays extensive length polymorphism. Therefore, this STR was studied in a large panel of animals, comprising pedigreed families as well. Sequencing analysis resulted in the detection of 60 Mafa-DRB exon 2 sequences that were unambiguously linked to the corresponding microsatellite. Its length is often allele specific and follows Mendelian segregation. In cynomolgus and rhesus macaques, the nucleotide composition of the DRB-STR is in concordance with the phylogeny of exon 2 sequences. As in humans and rhesus monkeys, this protocol detects specific combinations of different DRB-STR lengths that are unique for each haplotype. In the present panel, 22 Mafa-DRB region configurations could be defined, which exceeds the number detected in a comparable cohort of Indian rhesus macaques. The results suggest that, in cynomolgus monkeys, even more frequently than in rhesus macaques, new haplotypes are generated by recombination-like events. Although both macaque species are known to share several identical DRB exon 2 sequences, the lengths of the corresponding microsatellites often differ. Thus, this method allows not only fast and accurate DRB haplotyping but may also permit discrimination between highly related macaque species.
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