Evidence map›Paper›PMID 18956044›Full record

ArticleChemical communications (Cambridge, England)2008

Design of a novel molecular beacon: modification of the stem with artificially genetic alphabet.

Pinpin Sheng, Zunyi Yang, Youngmi Kim, Yanrong Wu, Weihong Tan, Steven A Benner

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Modified nucleotides may have enhanced early RNA catalysis.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Engineering molecular beacons for intracellular imaging.International journal of molecular imaging · 2012
    Article
  11. Expanded genetic alphabets in the polymerase chain reaction.Angewandte Chemie (International ed. in English) · 2010
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pinpin ShengDepartment of Chemistry and UF Genetics Institute, Shands Cancer Center, Center for Research at Bio/nano Interface and McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200, USA.
Zunyi Yang
Youngmi Kim
Yanrong Wu
Weihong Tan
Steven A Benner

Funding

Real-Time and Quantitative Determination of GenesR01GM066137 · NIGMS · UNIVERSITY OF FLORIDA · PI TAN, WEIHONG · 2002 to 2010
$2.2M
Artificial Genetic SystemsR01GM081527 · NIGMS · FOUNDATION FOR APPLIED MOLECULAR EVOLUTN · PI BENNER, STEVEN A · 2007 to 2010
$1.2M
NIGMS NIH HHS GM66137NIGMS NIH HHS R01 GM066137NIGMS NIH HHS R01 GM081527NIGMS NIH HHS R01GM081527
6 · The paper itself

Abstract

A molecular beacon that incorporates components of an artificially expanded genetic information system (Aegis) in its stem is shown not to be opened by unwanted stem invasion by adventitious standard DNA; this should improve the "darkness" of the beacon in real-world applications.

Indexed as

Base SequenceDNAFluorescent DyesMolecular Sequence DataOligonucleotide ProbesRNAThermodynamicsDNAFluorescent DyesOligonucleotide ProbesRNA

Identifiers

PMID18956044
PMCPMC2763601

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.