ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2009
Tissue inhibitor of matrix metalloproteinase-3 levels in the extracellular matrix of lung, kidney, and eye increase with age.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Spatial Mass Spectrometry-Based Proteomic Analysis of Normal-Appearing Glomeruli from Young and Old Adults.Kidney360 · 2025Article
- Microvascular aberrations found in human polycystic kidneys are an early feature in a Pkd1 mutant mouse model.Disease models & mechanisms · 2025Article
- Ranibizumab Modifies the Expression of Metalloproteinases and Their Tissue Inhibitors in Peripheral Blood Mononuclear Cells in Patients with Exudative Age-Related Macular Degeneration.Journal of clinical medicine · 2024Article
- Photoreceptor Layer Thinning Is an Early Biomarker for Age-Related Macular Degeneration: Epidemiologic and Genetic Evidence from UK Biobank OCT Data.Ophthalmology · 2022Article
- Tissue, age, sex, and disease patterns of matrisome expression in GTEx transcriptome data.Scientific reports · 2021Article
- Alterations in extracellular matrix composition during aging and photoaging of the skin.Matrix biology plus · 2020Article
- Relationship between vascular densities of choriocapillaris and the whole choroid using OCTA.International ophthalmology · 2020Article
- Loss of Complement Factor H impairs antioxidant capacity and energy metabolism of human RPE cells.Scientific reports · 2020Article
- Haplotypes ofDisease markers · 2019Article
- Extracellular matrix roles in cardiorenal fibrosis: Potential therapeutic targets for CVD and CKD in the elderly.Pharmacology & therapeutics · 2019Review
- Targeting Hif1a rescues cone degeneration and prevents subretinal neovascularization in a model of chronic hypoxia.Molecular neurodegeneration · 2018Article
- Changes in extracellular matrix cause RPE cells to make basal deposits and activate the alternative complement pathway.Human molecular genetics · 2018Article
- Elevated plasma levels of TIMP-3 are associated with a higher risk of acute respiratory distress syndrome and death following severe isolated traumatic brain injury.Trauma surgery & acute care open · 2018Article
- Complex Sources of Variation in Tissue Expression Data: Analysis of the GTEx Lung Transcriptome.American journal of human genetics · 2016Article
- Role of Protease-Inhibitors in Ocular Diseases.Molecules (Basel, Switzerland) · 2014Review
- Sulfated glycosaminoglycans control the extracellular trafficking and the activity of the metalloprotease inhibitor TIMP-3.Chemistry & biology · 2014Article
- A perspective on the role of the extracellular matrix in progressive retinal degenerative disorders.Investigative ophthalmology & visual science · 2013Review
- Aging is not a disease: distinguishing age-related macular degeneration from aging.Progress in retinal and eye research · 2013Review
- Influence of TIMP3/SYN3 polymorphisms on the phenotypic presentation of age-related macular degeneration.European journal of human genetics : EJHG · 2013Article
- Genetics of age-related macular degeneration: current concepts, future directions.Seminars in ophthalmology · 2011Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue inhibitor of matrix metalloproteinase-3 (TIMP-3) is an important regulator of matrix metalloproteinase activity in many types of disease, including atherosclerosis, neoplasia, and inflammatory conditions. Among TIMPs, TIMP-3 uniquely binds the extracellular matrix (ECM). We performed IHC staining on 17 tissue microarrays containing >1500 samples to determine the location of ECM TIMP-3 staining in a variety of predominantly vascular tissues. We found a unique pattern of TIMP-3 staining in the ECM of renal arterioles, small pulmonary vessels and parenchyma, and Bruch's membrane in the retina. There was no staining in larger caliber arteries including coronary and internal mammary arteries. TIMP-3 protein accumulation was found to be an age-dependent phenomenon, with staining appearing in all three tissues in early adulthood and becoming more robust among the elderly. These findings may help to explain the late onset of the TIMP-3-associated ocular diseases Sorsby fundus dystrophy and age-related macular degeneration and suggest a similar phenomenon could be at work in other age-related conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.