ArticleJournal of lipid research2009
Physiological consequences of disruption of mammalian phospholipid biosynthetic genes.
Article in Journal of lipid research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 75 citations in OpenAlex.
- Role of Glycerophospholipid Metabolism in Epilepsy.Current neuropharmacology · 2026Review
- Retinal neurovascular coupling dysfunction and plasma metabolomic features as biomarkers of Alzheimer's disease: an integrated diagnostic model.Frontiers in neuroscience · 2026Article
- Integrated Multiomics Analyses Reveal Molecular Insights into How Intermittent Fasting Ameliorates Obesity and Increases Fertility in Male Mice.Nutrients · 2025Article
- Cellular and organismal function of choline metabolism.Nature metabolism · 2025Review
- PCYT2 inhibits epithelial-mesenchymal transition in colorectal cancer by elevating YAP1 phosphorylation.JCI insight · 2024Article
- Rumen-Protected Choline Improves Metabolism and Lactation Performance in Dairy Cows.Animals : an open access journal from MDPI · 2024Article
- Phycobiliprotein Peptide Extracts fromNutrients · 2023Article
- The critical role of cardiolipin in metazoan differentiation, development, and maturation.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Review
- Article
- Lipidomics in non-alcoholic fatty liver disease.World journal of hepatology · 2020Review
- Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition.Science advances · 2019Article
- Differential network enrichment analysis reveals novel lipid pathways in chronic kidney disease.Bioinformatics (Oxford, England) · 2019Article
- Historical perspective: phosphatidylserine and phosphatidylethanolamine from the 1800s to the present.Journal of lipid research · 2018Article
- The Role of Mitochondrial Dysfunction in the Progression of Alzheimer's Disease.Current medicinal chemistry · 2018Review
- mTORC1 stimulates phosphatidylcholine synthesis to promote triglyceride secretion.The Journal of clinical investigation · 2017Article
- Lipidomic Evaluation of Aryl Hydrocarbon Receptor-Mediated Hepatic Steatosis in Male and Female Mice Elicited by 2,3,7,8-Tetrachlorodibenzo-p-dioxin.Chemical research in toxicology · 2017Article
- Normalization of Hepatic Homeostasis in theThe Journal of biological chemistry · 2017Article
- Protein Localization at Mitochondria-ER Contact Sites in Basal and Stress Conditions.Frontiers in cell and developmental biology · 2017Review
- Looking Beyond Structure: Membrane Phospholipids of Skeletal Muscle Mitochondria.Trends in endocrinology and metabolism: TEM · 2016Review
- Lipidomics analysis of follicular fluid by ESI-MS reveals potential biomarkers for ovarian endometriosis.Journal of assisted reproduction and genetics · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
By 1959, Eugene Kennedy and coworkers had outlined most pathways of phospholipid biosynthesis. In the next four decades, the emphasis was on enzymology and regulation of these pathways. In the last 12 years, several lines of mice with disrupted genes of phospholipid biosynthesis were generated. From this research, we have learned that embryonic lethality occurs in mice that lack choline kinase (CK) alpha, CTP:phosphocholine cytidylyltransferase alpha, CTP:phosphoethanolamine cytidylyltransferase, or phosphatidylserine decarboxylase. Whereas mice that lack CK beta are viable but develop hindlimb muscular dystrophy and neonatal bone deformity. Mice that lack CTP:phosphocholine cytidylytransferase beta have gonadal dysfunction and defective axon branching. Mice that lack phosphatidylethanolamine N-methyltransferase exhibit no phenotype until fed a choline-deficient diet, which leads to rapid liver failure. Future research should extend our knowledge about the function of these and other enzymes of phospholipid biosynthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.