Trial reportAmerican journal of Alzheimer's disease and other dementias
The usefulness of cube copying for evaluating treatment of Alzheimer's disease.
Trial report in American journal of Alzheimer's disease and other dementias. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Machine learning model for predicting the conversion to dementia using the Cube Copying Test.Journal of Alzheimer's disease : JAD · 2025Article
- Comprehensive Anatomical Staging Predicts Clinical Progression in Mild Cognitive Impairment: A Data-Driven Approach.International journal of molecular sciences · 2025Article
- Outcome of visuospatial dysfunction assessment in patients with Parkinson's disease using mobile application software.Frontiers in aging neuroscience · 2023Article
- Cognitively normal women with Alzheimer's disease proteinopathy show relative preservation of memory but not of hippocampal volume.Alzheimer's research & therapy · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsCube copying measures visuospatial ability, which is often impaired in Alzheimer's disease (AD). Cube copying was examined as an evaluation of cholinesterase inhibitor (ChEI) treatment in AD.
methodsEighty-five ChEI-treated AD patients were included. Cube drawings made at prebaseline, baseline, 6 months, and 12 months were assessed. Cube drawings from 56 healthy individuals were also examined.
resultsThe healthy individuals remained stable in cube copying, whereas untreated AD patients deteriorated during a median period of 6 months. When treatment was given, the deterioration was interrupted. After 12 months, Mini-Mental State Examination (MMSE) had deteriorated compared with baseline whereas cube copying was unchanged.
conclusionsThe results indicate that cube copying can be used to evaluate ChEI treatment. It might also show a more long-lasting response to treatment than MMSE. Cube copying only measures a narrow cognitive function and can preferably be used with MMSE, which evaluates visuospatial ability poorly.
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Registered trials
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