ArticleThe Journal of cell biology2008
Sonic Hedgehog signaling impairs ionizing radiation-induced checkpoint activation and induces genomic instability.
Article in The Journal of cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 63 citations in OpenAlex.
- Reappraisal of the Roles of the Sonic Hedgehog Signaling Pathway in Hepatocellular Carcinoma.Cancers · 2024Review
- Ribosome biosynthesis and Hedgehog activity are cooperative actionable signaling mechanisms in breast cancer following radiotherapy.NPJ precision oncology · 2023Article
- Downregulation of Sonic hedgehog signaling induces G2-arrest in genital warts.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2023Article
- Towards Precision Oncology: The Role of Smoothened and Its Variants in Cancer.Journal of personalized medicine · 2022Review
- Medulloblastoma and the DNA Damage Response.Frontiers in oncology · 2022Review
- Microgravity and space radiation inhibit autophagy in human capillary endothelial cells, through either opposite or synergistic effects on specific molecular pathways.Cellular and molecular life sciences : CMLS · 2021Article
- Elevated Hedgehog activity contributes to attenuated DNA damage responses in aged hematopoietic cells.Leukemia · 2020Article
- Nanog-driven cell-reprogramming and self-renewal maintenance in Ptch1Scientific reports · 2017Article
- Frequently mutated genes/pathways and genomic instability as prevention targets in liver cancer.Carcinogenesis · 2017Review
- Norrin/Frizzled4 signalling in the preneoplastic niche blocks medulloblastoma initiation.eLife · 2016Article
- Ionizing Radiation Exposure and Basal Cell Carcinoma Pathogenesis.Radiation research · 2016Review
- Promising Gene Therapeutics for Salivary Gland Radiotoxicity.AIMS medical science · 2016Article
- Review
- Review
- Deficient expression of aldehyde dehydrogenase 1A1 is consistent with increased sensitivity of Gorlin syndrome patients to radiation carcinogenesis.Molecular carcinogenesis · 2015Article
- A novel multiplexed, image-based approach to detect phenotypes that underlie chromosome instability in human cells.PloS one · 2015Article
- Pathways to chromothripsis.Cell cycle (Georgetown, Tex.) · 2015Article
- The transcription factor Cux1 in cerebellar granule cell development and medulloblastoma pathogenesis.Cerebellum (London, England) · 2014Article
- Gli1 protein regulates the S-phase checkpoint in tumor cells via Bid protein, and its inhibition sensitizes to DNA topoisomerase 1 inhibitors.The Journal of biological chemistry · 2014Article
- Gli1 contributes to cellular resistance to cisplatin through altered cellular accumulation of the drug.Oncology reports · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The Sonic Hedgehog (Shh) pathway plays important roles in embryogenesis, stem cell maintenance, tissue repair, and tumorigenesis. Haploinsufficiency of Patched-1, a gene that encodes a repressor of the Shh pathway, dysregulates the Shh pathway and increases genomic instability and the development of spontaneous and ionizing radiation (IR)-induced tumors by an unknown mechanism. Here we show that Ptc1(+/-) mice have a defect in the IR-induced activation of the ATR-Chk1 checkpoint signaling pathway. Likewise, transient expression of Gli1, a downstream target of Shh signaling, disrupts Chk1 activation in human cells by preventing the interaction of Chk1 with Claspin, a Chk1 adaptor protein that is required for Chk1 activation. These results suggest that inappropriate Shh pathway activation promotes tumorigenesis by disabling a key signaling pathway that helps maintain genomic stability and inhibits tumorigenesis.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.