ArticleInfection and immunity2009
Substrains of 129 mice are resistant to Yersinia pestis KIM5: implications for interleukin-10-deficient mice.
Article in Infection and immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Pathogenic Exploitation of Lymphatic Vessels.Cells · 2022Review
- Difference in Strain Pathogenicity of Septicemic Yersinia pestis Infection in a TLR2Infection and immunity · 2020Article
- Human Macrophages Clear the Biovar Microtus Strain ofFrontiers in cellular and infection microbiology · 2019Article
- Enterobacteria and host resistance to infection.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Resistance of Mice of the 129 Background to Yersinia pestis Maps to Multiple Loci on Chromosome 1.Infection and immunity · 2016Article
- Interleukin-10 induction is an important virulence function of the Yersinia pseudotuberculosis type III effector YopM.Infection and immunity · 2012Article
- Resistance to Yersinia pestis infection decreases with age in B10.T(6R) mice.Infection and immunity · 2011Article
- Mus spretus SEG/Pas mice resist virulent Yersinia pestis, under multigenic control.Genes and immunity · 2011Article
- Model systems to study plague pathogenesis and develop new therapeutics.Frontiers in microbiology · 2010Article
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Authors and funding
3 authors.
Funding
Abstract
Interleukin-10 (IL-10)-deficient mice are resistant to several pathogens, including Yersinia pestis. Surprisingly, we observed that heterozygous IL-10(+/-) mice also survive high-dose intravenous infection with Y. pestis KIM5 (Pgm(-)). Analysis of commercial IL-10(-/-) mice revealed that at least 30 cM of genomic DNA from the original 129 strain remains, including a functional Slc11a1 (Nramp1) gene. Interestingly, two substrains of 129 mice were resistant to high-dose Y. pestis KIM5. Resistance does not appear to be recessive, as F(1) mice (C57BL/6J x 129) also survived a high-dose challenge. A QTL-based genetic scan of chromosome 1 with 35 infected F(1) backcrossed mice revealed that resistance to KIM5 maps to a region near IL-10. Two novel IL-10(+/+) mouse strains which each possess most of the original 30-cM stretch of 129 DNA maintained resistance to high-dose infection with Y. pestis KIM5 even in a heterozygous state. Conversely, a novel IL-10(-/-) mouse strain in which most of the 129 DNA has been crossed out exhibited intermediate resistance to KIM5, while the corresponding IL-10(+/-) strain was completely susceptible. Taken together, these results demonstrate that 129-derived genomic DNA near IL-10 confers resistance to Yersinia pestis KIM5 and contributes to the observed resistance of IL-10(-/-) mice.
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