Trial reportThe Journal of physiology2008
Neuromuscular blockade of slow twitch muscle fibres elevates muscle oxygen uptake and energy turnover during submaximal exercise in humans.
Trial report in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 86 citations in OpenAlex.
- Menthol alleviates post-race elevations in muscle soreness and metabolic and respiratory stress during running.European journal of applied physiology · 2024Trial
- Effect of repeated forearm muscle cooling on the adaptation of skeletal muscle metabolism in humans.International journal of biometeorology · 2017Trial
- Leg vascular and skeletal muscle mitochondrial adaptations to aerobic high-intensity exercise training are enhanced in the early postmenopausal phase.The Journal of physiology · 2017Trial
- Sex Differences in Durability Following Heavy Intensity Cycling Exercise in Trained Athletes.Scandinavian journal of medicine & science in sports · 2026Article
- Why low-intensity endurance training for athletes?European journal of applied physiology · 2025Review
- Quantifying altered oxygen kinetics and reducing metabolic test times for children with cerebral palsy: a dual-exponential Bayesian modeling approach.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Physiological Resilience: What Is It and How Might It Be Trained?Scandinavian journal of medicine & science in sports · 2025Review
- The effects of low vs. high rating of perceived exertion clamp exercise on performance, neuromuscular, and muscle oxygen saturation responses in females.European journal of applied physiology · 2025Article
- The higher oxygen consumption during multiple short intervals is sex-independent and not influenced by skeletal muscle characteristics in well-trained cyclists.European journal of sport science · 2024Article
- Exercise intolerance in heart failure with preserved ejection fraction: Causes, consequences and the journey towards a cure.Experimental physiology · 2024Review
- Energy metabolism and muscle activation heterogeneity explainExperimental physiology · 2023Article
- Effect of Weight Self-Stigma and Self-Esteem on Aerobic Exercise Capacity in Adult Women with Different Body Compositions.International journal of environmental research and public health · 2022Article
- Is the Energy Cost of Rowing a Determinant Factor of Performance in Elite Oarsmen?Frontiers in physiology · 2022Article
- The metabolic profiles of different fiber type populations under the emergence of the slow component of oxygen uptake.The journal of physiological sciences : JPS · 2020Article
- "Work-to-Work" exercise slows pulmonary oxygen uptake kinetics, decreases critical power, and increases W' during supine cycling.Physiological reports · 2018Article
- Elevated baseline work rate slows pulmonary oxygen uptake kinetics and decreases critical power during upright cycle exercise.Physiological reports · 2018Article
- Effect of speed endurance training and reduced training volume on running economy and single muscle fiber adaptations in trained runners.Physiological reports · 2018Article
- A Lactate Kinetics Method for Assessing the Maximal Lactate Steady State Workload.Frontiers in physiology · 2018Article
- Pulmonary oxygen uptake and muscle deoxygenation kinetics during heavy intensity cycling exercise in patients with emphysema and idiopathic pulmonary fibrosis.BMC pulmonary medicine · 2017Article
- Pulmonary rehabilitation for COPD improves exercise time rather than exercise tolerance: effects and mechanisms.International journal of chronic obstructive pulmonary disease · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We tested the hypothesis that a greater activation of fast-twitch (FT) fibres during dynamic exercise leads to a higher muscle oxygen uptake (VO2 ) and energy turnover as well as a slower muscle on-kinetics. Subjects performed one-legged knee-extensor exercise for 10 min at an intensity of 30 W without (CON) and with (CUR) arterial injections of the non-depolarizing neuromuscular blocking agent cisatracurium. In CUR, creatine phosphate (CP) was unaltered in slow twitch (ST) fibres and decreased (P < 0.05) by 28% in FT fibres, whereas in CON, CP decreased (P < 0.05) by 33% and 23% in ST and FT fibres, respectively. From 127 s of exercise, muscle VO2 was higher (P < 0.05) in CUR compared to CON (425 +/- 25 (+/- S.E.M.) versus 332 +/- 30 ml min(-1)) and remained higher (P < 0.05) throughout exercise. Using monoexponential fitting, the time constant of the exercise-induced muscle VO2 response was slower (P < 0.05) in CUR than in CON (55 +/- 6 versus 33 +/- 5 s). During CUR and CON, muscle homogenate CP was lowered (P < 0.05) by 32 and 35%, respectively, and also muscle lactate production was similar in CUR and CON (37.8 +/- 4.1 versus 35.2 +/- 6.2 mmol). Estimated total muscle ATP turnover was 19% higher (P < 0.05) in CUR than in CON (1196 +/- 90 versus 1011 +/- 59 mmol) and true mechanical efficiency was lower (P < 0.05) in CUR than in CON (26.2 +/- 2.0 versus 30.9 +/- 1.5%). In conclusion, the present findings provide evidence that FT fibres are less efficient than ST fibres in vivo at a contraction frequency of 1 Hz, and that the muscle VO2 kinetics is slowed by FT fibre activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.