ArticleEvidence-based complementary and alternative medicine : eCAM2010
Immunostimulation-Mediated Anti-tumor Activity of Bamboo (Sasa senanensis) Leaf Extracts Obtained Under 'Vigorous' Condition.
Article in Evidence-based complementary and alternative medicine : eCAM, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 45 citations in OpenAlex.
- Bamboo-Enabled Nanomaterials for Biomedical Applications.Polymers · 2026Review
- Effects of Sasa veitchii extract on intestinal epithelial cells and gut microbiota.Journal of natural medicines · 2026Article
- Molecular approaches for enhancing fermented bamboo-derived feed additives: A sustainable nutritional innovation for poultry.Poultry science · 2025Review
- The neuroprotective effect of traditional Chinese medicinal plants-A critical review.Acta pharmaceutica Sinica. B · 2023Review
- Garlicnin B1, an Active Cyclic Sulfide from Garlic, Exhibits Potent Anti-Inflammatory and Anti-Tumor Activities.Antioxidants (Basel, Switzerland) · 2023Article
- Effects of bamboo leaf extract intervention on the growth performance, antioxidant capacity, and hepatic apoptosis in suckling piglets.Journal of animal science · 2022Article
- Extracts ofNutrients · 2020Article
- Article
- Sasa veitchii extracts suppress acetaminophen-induced hepatotoxicity in mice.Environmental health and preventive medicine · 2017Article
- Sasa veitchii extract suppresses carbon tetrachloride-induced hepato- and nephrotoxicity in mice.Environmental health and preventive medicine · 2016Article
- Potential Medicinal Application and Toxicity Evaluation of Extracts from Bamboo Plants.Journal of medicinal plant research · 2015Article
- Sasa quelpaertensis Leaf Extract Inhibits Colon Cancer by Regulating Cancer Cell Stemness in Vitro and in Vivo.International journal of molecular sciences · 2015Article
- Article
- Screening and analysis of the potential bioactive components in rabbit plasma after oral administration of hot-water extracts from leaves of Bambusa textilis McClure.Molecules (Basel, Switzerland) · 2012Article
- Rapid Screening for Flavone C-Glycosides in the Leaves of Different Species of Bamboo and Simultaneous Quantitation of Four Marker Compounds by HPLC-UV/DAD.International journal of analytical chemistry · 2012Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traditional Japanese medicine uses the leaves of Kumaizasa bamboo extracted in hot water at 100°C. For this study, we developed a new, 'vigorous' extraction method involving steps at 100, 121 and 196°C. This procedure not only yielded greater amounts of extract but also with significant increase in immunostimulating activity, which induces activation of human natural killer (NK) cells, macrophages and potent induction of IL-2, IL-12 and IFN-γ in tumor bearing mice. The efficacy of the extract to facilitate phagocytosis and nitric oxide production by mouse peritoneal macrophages was determined and compared with that of 1,3-β-glucan. Anti-tumor activity was evaluated in vivo in several mouse tumor models (S-180, C38 and Meth-A). Oral administration of the extracts was carried out when tumor reached size of approximately 6 mm at concentrations of 0.05% or higher. The extracts significantly suppressed tumor growth in S-180 and C38 tumor models. Overall survival was significantly prolonged in the treatment group than that of control. Activation of macrophages and NK cells by the extracts suggests that the anti-tumor efficacy of the extract is mediated by immunopotentiation. The extracts resolved into three major fractions (F-I, F-II and F-III) in Sephadex gel chromatography. Fraction F-I consists of 1,3-β-glucan and stimulated both macrophages and NK cells suggesting that it may be the primary immunopotentiating factor in suppressing cancer. Fraction F-III has potent free radical scavenging effects and may play an important role in cancer prevention. These results warrant further translation and clinical investigations.
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Registered trials
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