ArticleEvidence-based complementary and alternative medicine : eCAM2009
Ginseng on hyperglycemia: effects and mechanisms.
Article in Evidence-based complementary and alternative medicine : eCAM, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 35 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Comprehensive PRISMA Based Systematic Review: Exploring the Phytochemistry, Pharmacological Profile and Clinical aspects ofCurrent topics in medicinal chemistry · 2025Pooled it
- Pooled it
- Red ginseng for type 2 diabetes mellitus: a systematic review of randomized controlled trials.Chinese journal of integrative medicine · 2011Pooled it
- Postprandial glucose-lowering effects of fermented red ginseng in subjects with impaired fasting glucose or type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial.BMC complementary and alternative medicine · 2014Trial
- Using ginseng as a nutritional supplement in the quail diet and studying its effect on productive and physiological performance.Open veterinary journal · 2025Article
- Exploring the mechanism of active components from ginseng to manage diabetes mellitus based on network pharmacology and molecular docking.Scientific reports · 2023Article
- Ginseng, Tribulus Extracts and Pollen Grains Supplementation Improves Sexual State, Testes Redox Status, and Testicular Histology in Nile Tilapia Males.Antioxidants (Basel, Switzerland) · 2022Article
- Effect of Korean Red Ginseng on metabolic syndrome.Journal of ginseng research · 2021Review
- Needs and resources of people with type 2 diabetes in peri-urban Cochabamba, Bolivia: a people-centred perspective.International journal for equity in health · 2021Article
- Retracted: Ginseng on Hyperglycemia: Effects and Mechanisms.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- American Ginseng (Nutrients · 2019Review
- Pharmacology of natural radioprotectors.Archives of pharmacal research · 2018Review
- Article
- Evaluation of the toxicity and hypoglycemic effect of the aqueous extracts of Cnidoscolus quercifolius Pohl.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Article
- Protopanaxadiol and Protopanaxatriol-Type Saponins Ameliorate Glucose and Lipid Metabolism in Type 2 Diabetes Mellitus in High-Fat Diet/Streptozocin-Induced Mice.Frontiers in pharmacology · 2017Article
- The antitumor activity study of ginsenosides and metabolites in lung cancer cell.American journal of translational research · 2016Article
- Saponin as regulator of biofuel: implication for ethnobotanical management of diabetes.Journal of physiology and biochemistry · 2014Review
- Korean red ginseng extract alleviates advanced glycation end product-mediated renal injury.Journal of ginseng research · 2013Article
- Herbal therapies for type 2 diabetes mellitus: chemistry, biology, and potential application of selected plants and compounds.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- UPLC-Q-TOF-MS/MS Analysis for Steaming Times-dependent Profiling of Steamed Panax quinquefolius and Its Ginsenosides Transformations Induced by Repetitious Steaming.Journal of ginseng research · 2012Article
Corrections and comments
- Retraction · 2020-11-24Duplication of/in Article · Euphemisms for Duplication ·
- Retracted
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been reported that American ginseng attenuates hyperglycemia and may present itself as a supplement to diabetes therapy. However, the lack of standardization in the usage of ginseng root leads to inconclusive results when applied to diabetes treatment. The mechanisms of American ginseng root in the treatment of diabetes remains a mystery. This greatly limits the effective utilization of American ginseng in facilitating diabetic therapy. Initiating studies have shown that American ginseng increases insulin production and reduces cell death in pancreatic beta-cells. Also, studies have revealed American ginseng's ability to decrease blood glucose in type II diabetes patients as well as in streptozotocin-induced diabetic animals (STZ-diabetic mice). These data suggest that effects of ginseng in improving hyperglycemia may alter mitochondrial function as well as apoptosis cascades to ensure cell viability in pancreatic islet cells. This review briefly summarizes current knowledge of ginseng components and clinical studies related to diabetes. Further research will be needed to explore and identify the component(s) of ginseng, which may be responsible for the beneficial effects observed in animal studies which could then be extrapolated to human islets.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.