ArticleEvidence-based complementary and alternative medicine : eCAM2009
Evaluating complementary therapies for canine osteoarthritis--Part II: a homeopathic combination preparation (Zeel).
Article in Evidence-based complementary and alternative medicine : eCAM, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- Clinical validity of outcome pain measures in naturally occurring canine osteoarthritis.BMC veterinary research · 2012Trial
- Palmitoyl-glucosamine co-micronized with curcumin for maintenance of meloxicam-induced pain relief in dogs with osteoarthritis pain.BMC veterinary research · 2023Article
- A Systematic Review of Complementary and Alternative Veterinary Medicine: "Miscellaneous Therapies".Animals : an open access journal from MDPI · 2021Review
- Sanguinaria canadensis: Traditional Medicine, Phytochemical Composition, Biological Activities and Current Uses.International journal of molecular sciences · 2016Review
- Kinetic measurements of gait for osteoarthritis research in dogs and cats.The Canadian veterinary journal = La revue veterinaire canadienne · 2014Review
- A posteriori comparison of natural and surgical destabilization models of canine osteoarthritis.BioMed research international · 2013Article
- Effect of a diet enriched with green-lipped mussel on pain behavior and functioning in dogs with clinical osteoarthritis.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2013Article
- Brachystemma calycinum D. Don Effectively Reduces the Locomotor Disability in Dogs with Naturally Occurring Osteoarthritis: A Randomized Placebo-Controlled Trial.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Evaluating Complementary Therapies for Canine Osteoarthritis Part I: Green-lipped Mussel (Perna canaliculus).Evidence-based complementary and alternative medicine : eCAM · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A homeopathic combination preparation (HCP) for canine osteoarthritic pain was evaluated in a randomized, double-controlled and double-blinded clinical trial. Forty-four dogs with osteoarthritis (OA) that were randomly allocated into one of three groups completed the study. All dogs were fed test products or placebo for 8 weeks. The dogs were evaluated at the clinic four times, with 4-week intervals. Six different variables were assessed: veterinary-assessed mobility, two force plate variables, an owner-evaluated chronic pain index and pain and locomotion visual analogue scales (VASs). Intake of extra non-steroidal anti-inflammatory drugs was also evaluated. A Chi-squared test and a Mann-Whitney test were used to determine significant improvement between groups. When changed into dichotomous responses of 'improved' or 'not improved' three out of the six variables showed a significant difference (P = 0.016, P = 0.008, P = 0.039) in improved dogs per group, between the HCP group and the placebo group. The odds ratios were over one for the same variables. As extent of improvement in the variables from start to end of treatment, the HCP product was significantly more improved in four (P = 0.015, P = 0.028, P = 0.049, P = 0.020) of the six variables, compared with the placebo. Our results indicated that the HCP Zeel(R) was beneficial in alleviating chronic orthopedic pain in dogs although it was not as effective as carprofen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.