ArticleEvidence-based complementary and alternative medicine : eCAM2009
Hepatoprotective Activity of Licorice Water Extract against Cadmium-induced Toxicity in Rats.
Article in Evidence-based complementary and alternative medicine : eCAM, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 46 citations in OpenAlex.
- MKK4 Inhibitors-Recent Development Status and Therapeutic Potential.International journal of molecular sciences · 2023Review
- Dietary licorice enhances in vivo cadmium detoxification and modulates gut microbial metabolism in mice.iMeta · 2022Article
- GuUGT, a glycosyltransferase fromRoyal Society open science · 2019Article
- Licorisoflavan A Exerts Antidepressant-Like Effect in Mice: Involvement of BDNF-TrkB Pathway and AMPA Receptors.Neurochemical research · 2019Article
- The potential modulatory role of herbal additives against Cd toxicity in human, animal, and poultry: a review.Environmental science and pollution research international · 2019Article
- Dissecting the Metabolic Phenotype of the Antihypertensive Effects of FiveFrontiers in pharmacology · 2019Article
- Ethnopharmacological Approaches for Therapy of Jaundice: Part II. Highly Used Plant Species from Acanthaceae, Euphorbiaceae, Asteraceae, Combretaceae, and Fabaceae Families.Frontiers in pharmacology · 2017Review
- Glycyrrhizae radix methanol extract attenuates methamphetamine-induced locomotor sensitization and conditioned place preference.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Protective effects of Korean red ginseng extract on cadmium-induced hepatic toxicity in rats.Journal of ginseng research · 2013Article
- Inhibitory effects of glycyrrhetinic Acid on the delayed rectifier potassium current in Guinea pig ventricular myocytes and HERG channel.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Protective and therapeutic effects of licorice in rats with acute tubular necrosis.Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2012Article
- 18α-Glycyrrhizin induces apoptosis and suppresses activation of rat hepatic stellate cells.Medical science monitor : international medical journal of experimental and clinical research · 2012Article
- Herbal Medicine Containing Licorice May Be Contraindicated for a Patient with an HSD11B2 Mutation.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Phytomedicinal Role of Pithecellobium dulce against CCl(4)-mediated Hepatic Oxidative Impairments and Necrotic Cell Death.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Toxicity Profile of the Aqueous Ethanol Root Extract of Corrigiola telephiifolia Pourr. (Caryophyllaceae) in Rodents.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Effectiveness of Traditional Chinese Medicine for Liver Protection and Chemotherapy Completion among Cancer Patients.Evidence-based complementary and alternative medicine : eCAM · 2011Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Licorice is commonly used as a cure for digestive disorders and as a detoxification agent in East Asia. This study investigated the protective effect of licorice water extract against cadmium (CdCl(2), Cd)-induced liver toxicity in rats. To induce acute toxicity, Cd (4 mg/kg body weight) was dissolved in normal saline and intravenously (i.v.) injected into rats. The rats then received either a vehicle or licorice water extract (50, 100 mg/kg/day) for 3 days, and were subsequently exposed to a single injection of Cd 24 h after the last licorice/vehicle treatment. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) were significantly increased by Cd treatment. In contrast, pretreatment with licorice reduced ALT, AST and LDH. In histopathological analysis, licorice decreased the central necrosis around central veins, the peripheral hemorrhage around portal triads, the percentage of degenerative hepatic regions (%/mm(2) hepatic parenchyma) and the number of degenerative hepatic cells (N/100 hepatic cells). Licorice also inhibited the increment of Bad (a BH3 domain-containing protein) translocation by Cd in liver cells. These results demonstrate that licorice could have a hepatoprotective effect by inhibiting the translocation of Bad to the mitochondria in Cd-intoxificated rats.
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