ArticleEvidence-based complementary and alternative medicine : eCAM2008
Maintaining a physiological blood glucose level with 'glucolevel', a combination of four anti-diabetes plants used in the traditional arab herbal medicine.
Article in Evidence-based complementary and alternative medicine : eCAM, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 149 citations in OpenAlex.
- Pooled it
- Can daily consumption of enriched fatty acids diet be effective in improving metabolic syndrome? An attractive paradox for walnut kernel.Food science & nutrition · 2024Review
- Bioconverted Fruit Extract of Akebia Quinata Exhibits Anti-Obesity Effects in High-Fat Diet-Induced Obese Rats.Nutrients · 2022Article
- A review of the effects ofIranian journal of basic medical sciences · 2022Review
- Anti-Diabesity Middle Eastern Medicinal Plants and Their Action Mechanisms.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Article
- Medical Species Used in Russia for the Management of Diabetes and Related Disorders.Frontiers in pharmacology · 2021Review
- Metabolic and Epigenetics Action Mechanisms of Antiobesity Medicinal Plants and Phytochemicals.Evidence-based complementary and alternative medicine : eCAM · 2021Review
- Article
- Profiling Metabolites and Biological Activities of Sugarcane (Molecules (Basel, Switzerland) · 2019Article
- In vitro protein tyrosine phosphatase 1B inhibition and antioxidant property of different onion peel cultivars: A comparative study.Food science & nutrition · 2019Article
- Metabolic and Epigenetic Action Mechanisms of Antidiabetic Medicinal Plants.Evidence-based complementary and alternative medicine : eCAM · 2019Review
- Protective effect ofExperimental and therapeutic medicine · 2018Article
- The Effects ofIranian journal of medical sciences · 2017Article
- Role of traditional Islamic and Arabic plants in cancer therapy.Journal of traditional and complementary medicine · 2017Review
- Effect of novel blend nanofibrous scaffolds on diabetic wounds healing.IET nanobiotechnology · 2016Article
- Therapeutics role of olive fruits/oil in the prevention of diseases via modulation of anti-oxidant, anti-tumour and genetic activity.International journal of clinical and experimental medicine · 2014Review
- The globalization of traditional medicine in northern peru: from shamanism to molecules.Evidence-based complementary and alternative medicine : eCAM · 2013Review
- In Vitro Evaluations of Cytotoxicity of Eight Antidiabetic Medicinal Plants and Their Effect on GLUT4 Translocation.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Grape seed and tea extracts and catechin 3-gallates are potent inhibitors of α-amylase and α-glucosidase activity.Journal of agricultural and food chemistry · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Safety and anti-diabetic effects of Glucolevel, a mixture of dry extract of leaves of the Juglans regia L, Olea europea L, Urtica dioica L and Atriplex halimus L were evaluated using in vivo and in vitro test systems. No sign of toxic effects (using LDH assay) were seen in cultured human fibroblasts treated with increasing concentrations of Glucolevel. Similar observations were seen in vivo studies using rats (LD50: 25 g/kg). Anti-diabetic effects were evidenced by the augmentation of glucose uptake by yeast cells (2-folds higher) and by inhibition of glucose intestinal absorption ( approximately 49%) in a rat gut-segment. Furthermore, treatment with Glucolevel of Streptozotocin-induced diabetic rats for 2-3 weeks showed a significant reduction in glucose levels [above 400 +/- 50 mg/dl to 210 +/- 22 mg/dl (P < 0.001)] and significantly improved sugar uptake during the glucose tolerance test, compared with positive control. In addition, glucose levels were tested in sixteen human volunteers, with the recent onset of type 2 diabetes mellitus, who received Glucolevel tablets 1 x 3 daily for a period of 4 weeks. Within the first week of Glucolevel consumption, baseline glucose levels were significantly reduced from 290 +/- 40 to 210 +/- 20 mg/dl. At baseline, a subgroup of eleven of these subjects had glucose levels below 300 mg% and the other subgroup had levels >/= 300 mg%. Clinically acceptable glucose levels were achieved during the 2-3 weeks of therapy in the former subgroup and during the 4th week of therapy in the latter subgroup. No side effect was reported. In addition, a significant reduction in hemoglobin A1C values (8.2 +/- 1.03 to 6.9 +/- 0.94) was found in six patients treated with Glucolevel. Results demonstrate safety, tolerability and efficacy of herbal combinations of four plants that seem to act differently but synergistically to regulate glucose-homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.