ReviewBehavioural brain research2009
Ventral pallidum roles in reward and motivation.
Review in Behavioural brain research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 312 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
312 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- A neuroimaging meta-analysis on social impression formation of stable characteristics.Cerebral cortex (New York, N.Y. : 1991) · 2026Pooled it
- Neuroscience meets behavior: A systematic literature review on magnetic resonance imaging of the brain combined with real-world digital phenotyping.Human brain mapping · 2024Pooled it
- Brain connectivity changes underlying depression and fatigue in relapsing-remitting multiple sclerosis: A systematic review.PloS one · 2024Pooled it
- Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium.Biological psychiatry · 2020Pooled it
- Oxytocinergic modulation of speech production-a double-blind placebo-controlled fMRI study.Social cognitive and affective neuroscience · 2023Trial
- When does post-ingestive dopamine signaling occur in humans?bioRxiv : the preprint server for biology · 2026Article
- Brain-Wide Connectivity and Topographic Organization of Leptin Receptor Neurons in the Dorsomedial Hypothalamus.CNS neuroscience & therapeutics · 2026Article
- Frequency-dependent alterations of degree centrality in patients with poststroke depression: a resting-state functional MRI study.Neuroreport · 2026Article
- Unpacking Ventral Pallidum GABA Neuron Contributions to Opioid Drug Reward in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Distinct brain susceptibility alteration pattern in Parkinson's disease with drooling: evidence from quantitative susceptibility mapping.Quantitative imaging in medicine and surgery · 2026Article
- Article
- Complementary Sensitivity of Fixed-Time and Fixed-Oscillation Regimes to Exchange and Structural Disorder in the Human Brain Revealed Using Oscillating-Gradient Diffusion MRI With Ultra-Strong Gradients.Magnetic resonance in medicine · 2026Article
- Profiling Endogenous Opioid Peptide Release from Adrenal Chromaffin Cells.ACS chemical neuroscience · 2026Article
- The neuroanatomy and connectivity of the ventral striatum and ventral capsule area in the Göttingen minipig.Brain structure & function · 2026Article
- Sex Difference in Brain Responses During Short Abstinence in People With Internet Gaming Disorder.Addiction biology · 2026Article
- Most Ventral Pallidal Cholinergic Neurons Are Bursting Basal Forebrain Cholinergic Neurons with Mesocorticolimbic Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Aberrant type 2 dopamine and mu-opioid receptor availability in autism spectrum disorder.European journal of nuclear medicine and molecular imaging · 2026Article
- Differences in white matter structural networks in family risk of major depressive disorder and suicidality: A connectome analysis.Journal of affective disorders · 2026Article
- Ventral pallidum GABA neuron inhibition augments context-appropriate defensive responses to learned threat cues.Neurobiology of stress · 2026Article
- Single-cell sequencing of rodent ventral pallidum reveals diverse neuronal subtypes with noncanonical interregional continuity.Science advances · 2025Article
252 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
In recent years the ventral pallidum has become a focus of great research interest as a mechanism of reward and incentive motivation. As a major output for limbic signals, the ventral pallidum was once associated primarily with motor functions rather than regarded as a reward structure in its own right. However, ample evidence now suggests that ventral pallidum function is a major mechanism of reward in the brain. We review data indicating that (1) an intact ventral pallidum is necessary for normal reward and motivation, (2) stimulated activation of ventral pallidum is sufficient to cause reward and motivation enhancements, and (3) activation patterns in ventral pallidum neurons specifically encode reward and motivation signals via phasic bursts of excitation to incentive and hedonic stimuli. We conclude that the ventral pallidum may serve as an important 'limbic final common pathway' for mesocorticolimbic processing of many rewards.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.