ArticleBrain research2009
Proximal colon distension induces Fos expression in oxytocin-, vasopressin-, CRF- and catecholamines-containing neurons in rat brain.
Article in Brain research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Common brain activations for painful and non-painful aversive stimuli.BMC neuroscience · 2012Pooled it
- Neural signalling of gut mechanosensation in ingestive and digestive processes.Nature reviews. Neuroscience · 2022Review
- Functional disruption of cortical cingulate activity attenuates visceral hypersensitivity and anxiety induced by acute experimental colitis.Scientific reports · 2021Article
- Nucleus tractus solitarius mediates hyperalgesia induced by chronic pancreatitis in rats.World journal of gastroenterology · 2019Article
- Brain corticotropin-releasing factor signaling: Involvement in acute stress-induced visceral analgesia in male rats.Neurogastroenterology and motility · 2019Article
- Multiple Beneficial Effects of Ghrelin Agonist, HM01 on Homeostasis Alterations in 6-Hydroxydopamine Model of Parkinson's Disease in Male Rats.Frontiers in integrative neuroscience · 2019Article
- Associations Between Colonic Motor Patterns and Autonomic Nervous System Activity Assessed by High-Resolution Manometry and Concurrent Heart Rate Variability.Frontiers in neuroscience · 2019Article
- Contactless Assessment of Cerebral Autoregulation by Photoplethysmographic Imaging at Green Illumination.Frontiers in neuroscience · 2019Article
- Eating for 3.8 × 10Frontiers in endocrinology · 2018Review
- CNS sites activated by renal pelvic epithelial sodium channels (ENaCs) in response to hypertonic saline in awake rats.Autonomic neuroscience : basic & clinical · 2017Article
- Arginine Vasopressin and Arginine Vasopressin Receptor 1b Involved in Electroacupuncture-Attenuated Hypothalamic-Pituitary-Adrenal Axis Hyperactivity in Hepatectomy Rats.Neuromodulation : journal of the International Neuromodulation Society · 2016Article
- Stress and the Microbiota-Gut-Brain Axis in Visceral Pain: Relevance to Irritable Bowel Syndrome.CNS neuroscience & therapeutics · 2016Review
- Corticotrophin-releasing factor 1 activation in the central amygdale and visceral hyperalgesia.Neurogastroenterology and motility · 2015Review
- Article
- Brain somatostatin receptor 2 mediates the dipsogenic effect of central somatostatin and cortistatin in rats: role in drinking behavior.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Oxytocin decreases colonic motility of cold water stressed rats via oxytocin receptors.World journal of gastroenterology · 2014Article
- The Possible Neuronal Mechanism of Acupuncture: Morphological Evidence of the Neuronal Connection between Groin A-Shi Point and Uterus.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Ghrelin prevents levodopa-induced inhibition of gastric emptying and increases circulating levodopa in fasted rats.Neurogastroenterology and motility · 2012Article
- Modulation of physiological reflexes by pain: role of the locus coeruleus.Frontiers in integrative neuroscience · 2012Article
- Comparison of CRF-immunoreactive neurons distribution in mouse and rat brains and selective induction of Fos in rat hypothalamic CRF neurons by abdominal surgery.Brain research · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Little is known about the chemical coding of the brain neuronal circuitry activated by nociceptive signals of visceral origin. We characterized brain nuclei activated during isovolumetric phasic distension of the proximal colon (10 ml, 30 s on/off for 10 min) in conscious male rats, using Fos as a marker of neuronal activation and dual immunohistochemistry to visualize co-localization of Fos expression and oxytocin (OT), arginine-vasopressin (AVP), corticotrophin-releasing factor (CRF) or tyrosine hydroxylase (TH). Proximal colon distension, compared with sham distension, induced a robust increase in Fos-like immunoreactive (IR) neurons in the paraventricular nucleus (PVN), supraoptic nucleus (SON) and accessory neurosecretory nuclei of the hypothalamus, nucleus of the solitary tract (NTS) and ventrolateral medulla (VLM), and to a lower extent, in the locus coeruleus (LC) and Barrington nucleus. Fos-IR neurons in the PVN after colon distension were identified in 81% of OT-IR, 18% AVP-IR and 16% CRF-IR neurons, while in the SON it represented 36% of OT-IR and 16% AVP-IR. Catecholaminergic cell groups in the pons (LC) and medulla (VLM, NTS) were also activated by proximal colon distension. Of the TH-IR neurons in VLM and NTS, 74% and 42% respectively were double labeled. These results indicate that colon distension stimulates OT-, AVP- and CRF-containing hypothalamic neurons, likely involved in the integration of colonic sensory information to modulate autonomic outflow and pain-related responses. Activation of medullary catecholaminergic centers might reflect the afferent and efferent limbs of the functional responses associated to visceral pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.