ArticleBioorganic & medicinal chemistry2008
Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs.
Article in Bioorganic & medicinal chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Adamantane-based inhibitors of the influenza A M2 proton channel: structure-based design, biological evaluation, and synthetic approaches.RSC medicinal chemistry · 2026Review
- Asymmetric Synthesis of Noradamantane Scaffolds via Diphenylprolinol Silyl Ether-Mediated Domino Michael/Epimerization/Michael (or Aldol)/1,2-Addition Reactions.Angewandte Chemie (International ed. in English) · 2025Article
- Calcium Modulating Effect of Polycyclic Cages: A Suitable Therapeutic Approach Against Excitotoxic-induced Neurodegeneration.Mini reviews in medicinal chemistry · 2024Review
- Annulated carbamates are precursors for the ring contraction of the adamantane framework.RSC advances · 2022Article
- Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease.European journal of medicinal chemistry · 2022Article
- Exploring the size of the lipophilic unit of the soluble epoxide hydrolase inhibitors.Bioorganic & medicinal chemistry · 2019Article
- Pharmacological and Electrophysiological Characterization of Novel NMDA Receptor Antagonists.ACS chemical neuroscience · 2018Article
- Azapropellanes with anti-influenza a virus activity.ACS medicinal chemistry letters · 2014Article
- Easily accessible polycyclic amines that inhibit the wild-type and amantadine-resistant mutants of the M2 channel of influenza A virus.Journal of medicinal chemistry · 2014Article
- 3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant.Journal of medicinal chemistry · 2013Article
- Role of the viral hemagglutinin in the anti-influenza virus activity of newly synthesized polycyclic amine compounds.Antiviral research · 2013Article
- The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives.Chemical reviews · 2013Review
- 2-[(Adamantan-1-yl)amino-meth-yl]-4-chloro-phenol hemihydrate.Acta crystallographica. Section E, Structure reports online · 2012Article
- Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities.Bioorganic & medicinal chemistry · 2012Article
- Evaluation of a chiral cubane-based Schiff base ligand in asymmetric catalysis reactions.Beilstein journal of organic chemistry · 2012Article
- Exploring the size limit of templates for inhibitors of the M2 ion channel of influenza A virus.Journal of medicinal chemistry · 2011Article
- Huprines as a new family of dual acting trypanocidal-antiplasmodial agents.Bioorganic & medicinal chemistry · 2011Article
- Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines.Bioorganic & medicinal chemistry · 2009Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
The synthesis of several (3-noradamantyl)amines, [(3-noradamantyl)methyl]amines, (3,7-dimethyl-1-bisnoradamantyl)amines, and [(3,7-dimethyl-1-bisnoradamantyl)methyl]amines is reported. They were evaluated against a wide range of viruses and one of them inhibited the cytopathicity of influenza A virus at a concentration similar to that of amantadine. Several of the new polycyclic amines show an interesting activity as NMDA receptor antagonists. A rimantadine analogue displayed significant trypanocidal activity. Moreover, to further characterize the pharmacology of these compounds, their effects on dopamine uptake were also assessed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.