ArticleJournal of virology1991
Infection initiated by the RNA pregenome of a DNA virus.
Article in Journal of virology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Hepatitis B Virus Nucleocapsid Assembly.Journal of molecular biology · 2025Review
- An RNA-based system to study hepatitis B virus replication and evaluate antivirals.Science advances · 2023Article
- Pregenomic RNA Launch Hepatitis B Virus Replication System Facilitates the Mechanistic Study of Antiviral Agents and Drug-Resistant Variants on Covalently Closed Circular DNA Synthesis.Journal of virology · 2022Article
- Article
- Investigating the hepatitis B virus life cycle using engineered reporter hepatitis B viruses.Cancer science · 2018Article
- Single-cell analysis of covalently closed circular DNA copy numbers in a hepadnavirus-infected liver.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Emergence of drug-resistant populations of woodchuck hepatitis virus in woodchucks treated with the antiviral nucleoside lamivudine.Antimicrobial agents and chemotherapy · 1999Article
- Elimination of duck hepatitis B virus RNA-containing capsids in duck interferon-alpha-treated hepatocytes.Journal of virology · 1999Article
- Enrichment of a precore-minus mutant of duck hepatitis B virus in experimental mixed infections.Journal of virology · 1999Article
- Infection of ducklings with virus particles containing linear double-stranded duck hepatitis B virus DNA: illegitimate replication and reversion.Journal of virology · 1998Article
- Functional characterization of naturally occurring variants of human hepatitis B virus containing the core internal deletion mutation.Journal of virology · 1998Article
- Alphavirus-based expression vectors: strategies and applications.Proceedings of the National Academy of Sciences of the United States of America · 1996Review
- Hepatitis B virus nucleocapsid envelopment does not occur without genomic DNA synthesis.Journal of virology · 1996Article
- Detection of an RNase H activity associated with hepadnaviruses.Journal of virology · 1995Article
- Illegitimate replication of linear hepadnavirus DNA through nonhomologous recombination.Journal of virology · 1995Article
- pet, a small sequence distal to the pregenome cap site, is required for expression of the duck hepatitis B virus pregenome.Journal of virology · 1994Article
- Alphaviruses--vectors for the expression of heterologous genes.Trends in biotechnology · 1993Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We describe experiments demonstrating that after transfection into permissive cells, the RNA pregenome of an avian hepadnavirus, the duck hepatitis B virus, is infectious. Using a Sindbis virus expression vector, we showed that cytoplasmic synthesis of the pregenome resulted in hepadnaviral DNA synthesis. Moreover, complete infectious virus was produced from cells transfected with hepadnaviral pregenomic RNA. We conclude that the pregenome of hepadnaviruses can express all the proteins required for DNA synthesis as well as serve as a template for reverse transcription and that DNA resulting from pregenome expression can be utilized to establish a productive infection in pregenome-transfected cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.