ArticleJournal of molecular neuroscience : MN2009
Effects of ubiquilin 1 on the unfolded protein response.
Article in Journal of molecular neuroscience : MN, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- Article
- miR-337-5p promotes the development of cardiac hypertrophy by targeting Ubiquilin-1 (UBQLN1).Bioengineered · 2021Article
- Structure of hRpn10 Bound to UBQLN2 UBL Illustrates Basis for Complementarity between Shuttle Factors and Substrates at the Proteasome.Journal of molecular biology · 2019Article
- The MT-CO1 V83I Polymorphism is a Risk Factor for Primary Open-Angle Glaucoma in African American Men.Investigative ophthalmology & visual science · 2018Article
- Clinical significance of ubiquilin 1 in gastric cancer.Medicine · 2018Article
- The STI and UBA Domains of UBQLN1 Are Critical Determinants of Substrate Interaction and Proteostasis.Journal of cellular biochemistry · 2017Article
- MIR155 Regulation of Ubiquilin1 and Ubiquilin2: Implications in Cellular Protection and Tumorigenesis.Neoplasia (New York, N.Y.) · 2017Article
- Structures of Rpn1 T1:Rad23 and hRpn13:hPLIC2 Reveal Distinct Binding Mechanisms between Substrate Receptors and Shuttle Factors of the Proteasome.Structure (London, England : 1993) · 2016Article
- Ubiquilin1 represses migration and epithelial-to-mesenchymal transition of human non-small cell lung cancer cells.Oncogene · 2015Article
- Protein aggregation and degradation mechanisms in neurodegenerative diseases.American journal of neurodegenerative disease · 2013Article
- Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Involvement of ubiquilin-1 transcript variants in protein degradation and accumulation.Communicative & integrative biology · 2011Article
- Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation.Traffic (Copenhagen, Denmark) · 2011Article
- Article
- Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability.The Journal of biological chemistry · 2009Article
- Recent advances in our understanding of neurodegeneration.Journal of neural transmission (Vienna, Austria : 1996) · 2009Review
- Ubiquitin-like and ubiquitin-associated domain proteins: significance in proteasomal degradation.Cellular and molecular life sciences : CMLS · 2009Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have implicated the unfolded protein response (UPR) in the pathogenesis of Alzheimer's disease (AD). We previously reported that DNA variants in the ubiquilin 1 (UBQLN1) gene increase the risk for AD. Since UBQLN1 has been shown to play a role in the UPR, we assessed the effects of overexpression and downregulation of UBQLN1 splice variants during tunicamycin-induced ER stress. In addition to previously described transcript variants, TV1 and TV2, we identified two novel transcript variants of UBQLN1 in brain: TV3 (lacking exons 2-4) and TV4 (lacking exon 4). Overexpression of TV1-3, but not TV4 significantly decreased the mRNA induction of UPR-inducible genes, C/EBP homologous protein (CHOP), BiP/GRP78, and protein disulfide isomerase (PDI) during the UPR. Stable overexpression of TV1-3, but not TV4, also significantly decreased the induction of CHOP protein and increased cell viability during the UPR. In contrast, downregulation of UBQLN1 did not affect CHOP mRNA induction, but instead increased PDI mRNA levels. These findings suggest that overexpression UBQLN1 transcript variants TV1-3, but not TV4, exert a protective effect during the UPR by attenuating CHOP induction and potentially increasing cell viability.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.