ArticleJournal of molecular histology2008
Vitamin E supplementation in rats with experimental diabetes mellitus: analysis of myosin-V and nNOS immunoreactive myenteric neurons from terminal ileum.
Article in Journal of molecular histology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Diabetes-Related Induction of the Heme Oxygenase System and Enhanced Colocalization of Heme Oxygenase 1 and 2 with Neuronal Nitric Oxide Synthase in Myenteric Neurons of Different Intestinal Segments.Oxidative medicine and cellular longevity · 2017Article
- Antioxidant Effects of the Quercetin in the Jejunal Myenteric Innervation of Diabetic Rats.Frontiers in medicine · 2017Article
- Is L-glutathione more effective than L-glutamine in preventing enteric diabetic neuropathy?Digestive diseases and sciences · 2014Article
- Molecular handoffs in nitrergic neurotransmission.Frontiers in medicine · 2014Review
- Myosin Va but Not nNOSα is Significantly Reduced in Jejunal Musculomotor Nerve Terminals in Diabetes Mellitus.Frontiers in medicine · 2014Article
- Diabetic neuropathy: an evaluation of the use of quercetin in the cecum of rats.World journal of gastroenterology · 2013Article
- Neuroprotective effect of quercetin on the duodenum enteric nervous system of streptozotocin-induced diabetic rats.Digestive diseases and sciences · 2012Article
- Diabetes-related alterations in the enteric nervous system and its microenvironment.World journal of diabetes · 2012Article
- 2, 3, 5, 4'-Tetrahydroxystilbene-2-O-beta-D-glucoside improves gastrointestinal motility disorders in STZ-induced diabetic mice.PloS one · 2012Article
- Morphofunctional changes underlying intestinal dysmotility in diabetic RIP-I/hIFNβ transgenic mice.International journal of experimental pathology · 2011Article
- L-glutamine supplementation prevents myenteric neuron loss and has gliatrophic effects in the ileum of diabetic rats.Digestive diseases and sciences · 2011Article
- Myosin Va plays a key role in nitrergic neurotransmission by transporting nNOSα to enteric varicosity membrane.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- Neuroprotective action of Ginkgo biloba on the enteric nervous system of diabetic rats.World journal of gastroenterology · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of vitamin E (1 g/kg body weight) supplementation on myosin-V and neuronal nitric oxide synthase (nNOS) immunoreactive myenteric neurons from the ileum of diabetic rats was investigated in the present study. Forty animals were divided into the following groups: normoglycemics (N), normoglycemics treated with vitamin E (NE), diabetics (D), and diabetics treated with vitamin E (DE). Quantitative and morphometric analyses were performed. The area of the tertiary plexus was also determined. Diabetes produced a 24% reduction in the number of myosin-V neurons in group D compared with group N, an effect that was accompanied by an increase in the tertiary plexus area (P < 0.05). Neuronal density was 27% higher in group NE than group N (P < 0.05). Nitrergic neuronal density was not altered as a consequence of either diabetes or vitamin E treatment. Myosin-V and nNOS immunoreactive neuronal cell body area increased significantly in group NE. The area of myosin-V and nNOS myenteric neurons also increased in group D. Vitamin E treatment (group DE) increased only the size of nitrergic neurons. The present results suggest that vitamin E elicited a neuroprotective and neurotrophic effect on the natural aging process, but with regard to diabetes, vitamin E supplementation exerted a neurotrophic effect only on nitrergic neurons.
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