ArticleJournal of molecular evolution2008
Positive Darwinian selection at single amino acid sites conferring plant virus resistance.
Article in Journal of molecular evolution, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- Molecular Mechanisms of Potato Plant-Virus-Vector Interactions.Plants (Basel, Switzerland) · 2025Review
- All Roads Lead to Rome: Pathways to Engineering Disease Resistance in Plants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Plant eIF4E isoforms as factors of susceptibility and resistance to potyviruses.Frontiers in plant science · 2023Review
- Resistance induction based on the understanding of molecular interactions between plant viruses and host plants.Virology journal · 2021Review
- Overexpression of a modified eIF4E regulates potato virus Y resistance at the transcriptional level in potato.BMC genomics · 2020Article
- Mimicking natural polymorphism in eIF4E by CRISPR-Cas9 base editing is associated with resistance to potyviruses.Plant biotechnology journal · 2019Article
- Genetic Engineering for Disease Resistance in Plants: Recent Progress and Future Perspectives.Plant physiology · 2019Review
- Nature of selection varies on different domains of IFI16-like PYHIN genes in ruminants.BMC evolutionary biology · 2019Article
- Geographical gradient of the eIF4E alleles conferring resistance to potyviruses in pea (Pisum) germplasm.PloS one · 2014Article
- A series of eIF4E alleles at the Bc-3 locus are associated with recessive resistance to Clover yellow vein virus in common bean.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2013Article
- Potato virus Y: a major crop pathogen that has provided major insights into the evolution of viral pathogenicity.Molecular plant pathology · 2013Review
- Evolution and variability of Solanum RanGAP2, a cofactor in the incompatible interaction between the resistance protein GPA2 and the Globodera pallida effector Gp-RBP-1.BMC evolutionary biology · 2013Article
- The Y-segment of novel cold dehydrin genes is conserved and codons in the PR-10 genes are under positive selection in Oxytropis (Fabaceae) from contrasting climates.Molecular genetics and genomics : MGG · 2012Article
- Historical contingencies modulate the adaptability of Rice yellow mottle virus.PLoS pathogens · 2012Article
- Coevolution and hierarchical interactions of Tomato mosaic virus and the resistance gene Tm-1.PLoS pathogens · 2012Article
- Selective sweeps for recessive alleles and for other modes of dominance.Journal of mathematical biology · 2011Article
- EcoTILLING in Capsicum species: searching for new virus resistances.BMC genomics · 2010Article
- Identification of a second major resistance gene to Rice yellow mottle virus, RYMV2, in the African cultivated rice species, O. glaberrima.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2010Article
- Phylogenetic analysis of ADP-glucose pyrophosphorylase subunits reveals a role of subunit interfaces in the allosteric properties of the enzyme.Plant physiology · 2009Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Explicit evaluation of the accuracy and power of maximum likelihood and Bayesian methods for detecting site-specific positive Darwinian selection presents a challenge because selective consequences of single amino acid changes are generally unknown. We exploited extensive molecular and functional characterization of amino acid substitutions in the plant gene eIF4E to evaluate the performance of these methods in detecting site-specific positive selection. We documented for the first time a molecular signature of positive selection within a recessive resistance gene in plants. We then used two statistical platforms, Phylogenetic Analysis Using Maximum Likelihood and Hypothesis Testing Using Phylogenies (HyPhy), to look for site-specific positive selection. Their relative power and accuracy are assessed by comparing the sites they identify as being positively selected with those of resistance-determining amino acids. Our results indicate that although both methods are surprisingly accurate in their identification of resistance sites, HyPhy appears to more accurately identify biologically significant amino acids using our data set.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.