ArticleRheumatology international2009
Clinical features of ankylosing spondylitis may correlate with HLA-B27 polymorphism.
Article in Rheumatology international, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association of HLA-B27 with ankylosing spondylitis and clinical features of the HLA-B27-associated ankylosing spondylitis: a meta-analysis.Rheumatology international · 2017Pooled it
- Safety of tumor necrosis factor-alpha inhibitors for treatment of ankylosing spondylitis: A meta-analysis.Medicine · 2017Pooled it
- Low Frequency of HLA-B27 in Ankylosing Spondylitis Patients from Turkey: Insights from the Thrace Region.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Associations between HLA-B27 subtypes and outcomes in Thai children with enthesitis-related arthritis.Clinical rheumatology · 2022Article
- Spondyloarthritis in North Africa: an update.Clinical rheumatology · 2021Review
- Article
- HLA-subtypes B*27 and ankylosing spondylitis features comments on Fellahi's article "Are early onset of disease and uveitis affected by HLA- subtypes B*27 in ankylosing spondylitis?"Clinical rheumatology · 2021Article
- Disease-Modifying Effects of Long-Term and Continuous Use of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in Spondyloarthritis.Advances in pharmacological sciences · 2019Review
- Does HLA-B27 Status Influence Ankylosing Spondylitis Phenotype?Clinical medicine insights. Arthritis and musculoskeletal disorders · 2018Review
- Low frequency of HLA-B27 in ankylosing spondylitis and its relationship with clinical findings in patients from Turkey.European journal of rheumatology · 2017Article
- An Update on the Genetic Polymorphism of HLA-B*27 With 213 Alleles Encompassing 160 Subtypes (and Still Counting).Current rheumatology reports · 2017Review
- Clinical Features in Juvenile-Onset Ankylosing Spondylitis Patients Carrying Different B27 Subtypes.BioMed research international · 2015Article
- A polymorphism in ERAP1 is associated with susceptibility to ankylosing spondylitis in a Turkish population.Rheumatology international · 2013Article
- Ankylosing Spondylitis: A rheumatology clinic experience.Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study is to investigate the relationship between clinical features of ankylosing spondylitis (AS) and HLA-B27 status or its subtypes. Clinical data and blood samples were collected with patients' informed consent. Luminex liquid array combining polymerase chain reaction-sequence specific oligonucleotide probe was used to do the low-resolution HLA-B genotype typing. Polymerase chain reaction-sequence specific primer was applied to do the high resolution HLA-B27 typing. In 98 subjects, 93 were HLA-B27 positive, of which three subtypes were detected: B*2704 (n = 76), B*2705 (n = 12), and B*2715 (n = 5). The onset age for B27 negative and positive group was 28 +/- 7.9 and 21.1 +/- 6.2 years, respectively (chi(2) = -2.047, P = 0.041). The onset age for B*2704, B*2705 and B*2715 group was 20.45 +/- 4.50, 26.67 +/- 9.95 and 17.8 +/- 11.12 years, respectively (chi(2) = 7.888, P = 0.019). No significant difference was found between B27 positive and negative group, or among three B27 subtypes groups for other clinical features. In conclusion, the clinical features of AS may be correlated with HLA-B27 status and its polymorphism.
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