ArticleNature2008
Generation of cell polarity in plants links endocytosis, auxin distribution and cell fate decisions.
Article in Nature, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 106 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
106 citing papers in PubMed, 239 citations in OpenAlex.
- FAB1C, a phosphatidylinositol 3-phosphate 5-kinase, interacts with PIN-FORMEDs and modulates their lytic trafficking in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Characterization of the PIN Auxin Efflux Carrier Gene Family and Its Expression during Zygotic Embryogenesis inPlants (Basel, Switzerland) · 2023Article
- Induction of Somatic Embryogenesis in Plants: Different Players and Focus on WUSCHEL and WUS-RELATED HOMEOBOX (WOX) Transcription Factors.International journal of molecular sciences · 2022Review
- PIN1 regulates epidermal cells development under drought and salt stress using single-cell analysis.Frontiers in plant science · 2022Article
- Biosynthesis and Roles of Salicylic Acid in Balancing Stress Response and Growth in Plants.International journal of molecular sciences · 2021Review
- The Arabidopsis R-SNARE VAMP714 is essential for polarisation of PIN proteins and auxin responses.The New phytologist · 2021Article
- An essential role for Arabidopsis Trs33 in cell growth and organization in plant apical meristems.Plant cell reports · 2020Article
- PIN2 Polarity Establishment inBiomolecules · 2019Article
- STO and GA negatively regulate UV-B-inducedPlant signaling & behavior · 2019Article
- SlPIN1 regulates auxin efflux to affect flower abscission process.Scientific reports · 2017Article
- GTPase ROP2 binds and promotes activation of target of rapamycin, TOR, in response to auxin.The EMBO journal · 2017Article
- Down-regulation of GIGANTEA-like genes increases plant growth and salt stress tolerance in poplar.Plant biotechnology journal · 2017Article
- The M3 Phosphorylation Site Is Required for Trafficking and Biological Roles of PIN-FORMED1, 2, and 7 inFrontiers in plant science · 2016Article
- Cellular mechanisms for cargo delivery and polarity maintenance at different polar domains in plant cells.Cell discovery · 2016Article
- Article
- Genetical genomics of Populus leaf shape variation.BMC plant biology · 2015Article
- Trafficking of plant plasma membrane aquaporins: multiple regulation levels and complex sorting signals.Plant & cell physiology · 2015Review
- Article
- Plant nutrition: root transporters on the move.Plant physiology · 2014Article
- Plant cells use auxin efflux to explore geometry.Scientific reports · 2014Article
46 more citing papers are in PubMed but not listed here.
Corrections and comments
- Retraction · 2014-07-16Results Not Reproducible · Unreliable Results and/or Conclusions ·
- Retracted
Authors and funding
15 authors at 5 institutions in 5 countries.
Funding
Abstract
Dynamically polarized membrane proteins define different cell boundaries and have an important role in intercellular communication-a vital feature of multicellular development. Efflux carriers for the signalling molecule auxin from the PIN family are landmarks of cell polarity in plants and have a crucial involvement in auxin distribution-dependent development including embryo patterning, organogenesis and tropisms. Polar PIN localization determines the direction of intercellular auxin flow, yet the mechanisms generating PIN polarity remain unclear. Here we identify an endocytosis-dependent mechanism of PIN polarity generation and analyse its developmental implications. Real-time PIN tracking showed that after synthesis, PINs are initially delivered to the plasma membrane in a non-polar manner and their polarity is established by subsequent endocytic recycling. Interference with PIN endocytosis either by auxin or by manipulation of the Arabidopsis Rab5 GTPase pathway prevents PIN polarization. Failure of PIN polarization transiently alters asymmetric auxin distribution during embryogenesis and increases the local auxin response in apical embryo regions. This results in ectopic expression of auxin pathway-associated root-forming master regulators in embryonic leaves and promotes homeotic transformation of leaves to roots. Our results indicate a two-step mechanism for the generation of PIN polar localization and the essential role of endocytosis in this process. It also highlights the link between endocytosis-dependent polarity of individual cells and auxin distribution-dependent cell fate establishment for multicellular patterning.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.