ArticleNucleic acids research2009
VarySysDB: a human genetic polymorphism database based on all H-InvDB transcripts.
Article in Nucleic acids research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- The PIK3CA/AKT pathway drives therapy resistance in rhabdomyosarcoma.Nature communications · 2025Article
- Selection pressure on human STR loci and its relevance in repeat expansion disease.Molecular genetics and genomics : MGG · 2016Article
- VaDE: a manually curated database of reproducible associations between various traits and human genomic polymorphisms.Nucleic acids research · 2015Article
- H-InvDB in 2013: an omics study platform for human functional gene and transcript discovery.Nucleic acids research · 2013Article
- Finding protein-coding genes through human polymorphisms.PloS one · 2013Article
- Article
- Pathway analysis using genome-wide association study data for coronary restenosis--a potential role for the PARVB gene.PloS one · 2013Article
- Prediction of protein-destabilizing polymorphisms by manual curation with protein structure.PloS one · 2012Article
- NovelSNPer: A Fast Tool for the Identification and Characterization of Novel SNPs and InDels.Advances in bioinformatics · 2011Article
- The rules of variation: amino acid exchange according to the rotating circular genetic code.Journal of theoretical biology · 2010Article
- A comprehensive survey of human polymorphisms at conserved splice dinucleotides and its evolutionary relationship with alternative splicing.BMC evolutionary biology · 2010Article
- Convergence of linkage, gene expression and association data demonstrates the influence of the RAR-related orphan receptor alpha (RORA) gene on neovascular AMD: a systems biology based approach.Vision research · 2010Article
- Mapping complex disease traits with global gene expression.Nature reviews. Genetics · 2009Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Creation of a vast variety of proteins is accomplished by genetic variation and a variety of alternative splicing transcripts. Currently, however, the abundant available data on genetic variation and the transcriptome are stored independently and in a dispersed fashion. In order to provide a research resource regarding the effects of human genetic polymorphism on various transcripts, we developed VarySysDB, a genetic polymorphism database based on 187,156 extensively annotated matured mRNA transcripts from 36,073 loci provided by H-InvDB. VarySysDB offers information encompassing published human genetic polymorphisms for each of these transcripts separately. This allows comparisons of effects derived from a polymorphism on different transcripts. The published information we analyzed includes single nucleotide polymorphisms and deletion-insertion polymorphisms from dbSNP, copy number variations from Database of Genomic Variants, short tandem repeats and single amino acid repeats from H-InvDB and linkage disequilibrium regions from D-HaploDB. The information can be searched and retrieved by features, functions and effects of polymorphisms, as well as by keywords. VarySysDB combines two kinds of viewers, GBrowse and Sequence View, to facilitate understanding of the positional relationship among polymorphisms, genome, transcripts, loci and functional domains. We expect that VarySysDB will yield useful information on polymorphisms affecting gene expression and phenotypes. VarySysDB is available at http://h-invitational.jp/varygene/.
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Registered trials
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