ArticleThe Journal of biological chemistry2009
Regulation of the heme A biosynthetic pathway: differential regulation of heme A synthase and heme O synthase in Saccharomyces cerevisiae.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Mechanisms of heme transport in the mitochondria.Biochemical Society transactions · 2025Review
- Evidence that the catalytic mechanism of heme a synthase involves the formation of a carbocation stabilized by a conserved glutamate.Archives of biochemistry and biophysics · 2023Article
- Comprehensive Characterization of MutantJournal of microbiology and biotechnology · 2022Article
- Mössbauer-based molecular-level decomposition of the Saccharomyces cerevisiae ironome, and preliminary characterization of isolated nuclei.Metallomics : integrated biometal science · 2022Article
- Article
- Review
- Biosynthesis of heme O in intraerythrocytic stages of Plasmodium falciparum and potential inhibitors of this pathway.Scientific reports · 2019Article
- Cox15 interacts with the cytochromeThe Journal of biological chemistry · 2018Article
- Analysis of Oligomerization Properties of Heme a Synthase Provides Insights into Its Function in Eukaryotes.The Journal of biological chemistry · 2016Article
- Opa1 overexpression ameliorates the phenotype of two mitochondrial disease mouse models.Cell metabolism · 2015Article
- Engineering the assembly of heme cofactors in man-made proteins.Journal of the American Chemical Society · 2014Article
- Structure, function, and assembly of heme centers in mitochondrial respiratory complexes.Biochimica et biophysica acta · 2012Review
- Oligomerization of heme o synthase in cytochrome oxidase biogenesis is mediated by cytochrome oxidase assembly factor Coa2.The Journal of biological chemistry · 2012Article
- Selective Oma1 protease-mediated proteolysis of Cox1 subunit of cytochrome oxidase in assembly mutants.The Journal of biological chemistry · 2012Article
- The role of Coa2 in hemylation of yeast Cox1 revealed by its genetic interaction with Cox10.Molecular and cellular biology · 2010Article
- Analysis of the genes coding for subunit 10 and 15 of cytochrome c oxidase in Alzheimer's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2009Article
- Surf1, associated with Leigh syndrome in humans, is a heme-binding protein in bacterial oxidase biogenesis.The Journal of biological chemistry · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The assembly and activity of cytochrome c oxidase is dependent on the availability of heme A, one of its essential cofactors. In eukaryotes, two inner mitochondrial membrane proteins, heme O synthase (Cox10) and heme A synthase (Cox15), are required for heme A biosynthesis. In this report, we demonstrate that in Saccharomyces cerevisiae the transcription of COX15 is regulated by Hap1, a transcription factor whose activity is positively controlled by intracellular heme concentration. Conversely, COX10, the physiological partner of COX15, does not share the same regulatory mechanism with COX15. Interestingly, protein quantification identified an 8:1 protein ratio between Cox15 and Cox10. Together, these results suggest that heme A synthase and/or heme O synthase might play a new, unidentified role in addition to heme A biosynthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.