ArticleInvestigative ophthalmology & visual science2009
Blood flow magnetic resonance imaging of retinal degeneration.
Article in Investigative ophthalmology & visual science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed, 34 citations in OpenAlex.
- Adaptive scan intervals in ultrawide-field OCT angiography achieved by a bidirectional interleaved approach.Biomedical optics express · 2026Article
- Layer-Specific Manganese-Enhanced MRI of the Diabetic Rat Retina in Light and Dark Adaptation at 11.7 Tesla.Investigative ophthalmology & visual science · 2015Article
- En face Doppler total retinal blood flow measurement with 70 kHz spectral optical coherence tomography.Journal of biomedical optics · 2015Article
- In vivo assessment of aqueous humor dynamics upon chronic ocular hypertension and hypotensive drug treatment using gadolinium-enhanced MRI.Investigative ophthalmology & visual science · 2014Article
- Decreased retinal-choroidal blood flow in retinitis pigmentosa as measured by MRI.Documenta ophthalmologica. Advances in ophthalmology · 2013Article
- MR imaging of papilledema and visual pathways: effects of increased intracranial pressure and pathophysiologic mechanisms.AJNR. American journal of neuroradiology · 2013Review
- Pharmacological MRI of the choroid and retina: blood flow and BOLD responses during nitroprusside infusion.Magnetic resonance in medicine · 2012Article
- Reduced ocular blood flow as an early indicator of diabetic retinopathy in a mouse model of diabetes.Investigative ophthalmology & visual science · 2012Article
- Layer-specific blood-flow MRI of retinitis pigmentosa in RCS rats.Experimental eye research · 2012Article
- Layer-specific manganese-enhanced MRI of the retina in light and dark adaptation.Investigative ophthalmology & visual science · 2012Article
- Blood flow MRI of the human retina/choroid during rest and isometric exercise.Investigative ophthalmology & visual science · 2012Article
- 3D magnetic resonance microscopy of the ex vivo retina.Magnetic resonance in medicine · 2012Article
- Review: magnetic resonance imaging techniques in ophthalmology.Molecular vision · 2012Review
- Layer-specific functional and anatomical MRI of the retina with passband balanced SSFP.Magnetic resonance in medicine · 2011Article
- Background suppression in arterial spin labeling MRI with a separate neck labeling coil.NMR in biomedicine · 2011Article
- Lamina-specific anatomic magnetic resonance imaging of the human retina.Investigative ophthalmology & visual science · 2011Article
- Anatomical, blood oxygenation level-dependent, and blood flow MRI of nonhuman primate (baboon) retina.Magnetic resonance in medicine · 2011Article
- Lamina-specific functional MRI of retinal and choroidal responses to visual stimuli.Investigative ophthalmology & visual science · 2011Article
- Effects of common anesthetics on eye movement and electroretinogram.Documenta ophthalmologica. Advances in ophthalmology · 2011Article
- MRI of blood flow of the human retina.Magnetic resonance in medicine · 2011Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
purposeThis study aims to investigate quantitative basal blood flow as well as hypercapnia- and hyperoxia-induced blood flow changes in the retinas of the Royal College of Surgeons (RCS) rats with spontaneous retinal degeneration, and to compare with those of normal rat retinas.
methodsExperiments were performed on male RCS rats at post-natal days P90 (n=4) and P220 (n=5), and on age-matched controls at P90 (n=7) and P220 (n=6). Hyperoxic (100% O(2)) and hypercapnic (5% CO(2), 21% O(2), balance N(2)) challenges were used to modulate blood flow. Quantitative baseline blood flow, and hypercapnia- and hyperoxia-induced blood flow changes in the retinas were imaged using continuous arterial spin labeling MRI at 90 x 90 x 1500 microm.
resultsIn the normal rat retinas, basal blood flow of the whole-retina was 5.5 mL/gram per min, significantly higher than those reported in the brain (approximately 1 mL/gram per min). Hyperoxia decreased blood flow due to vasoconstriction and hypercapnia increased blood flow due to vasodilation in the normal retinas. In the RCS rat retinas, basal blood flow was diminished significantly (P<0.05). Interestingly, absolute hyperoxia- and hypercapnia-induced blood flow changes in the RCS retinas were not statistically different from those in the normal retinas (P>0.05). However, blood flow percent changes in RCS retinas were significantly larger than in normal retinas due to lower basal blood flow in the RCS retinas.
conclusionsRetinal degeneration markedly reduces basal blood flow but does not appear to impair vascular reactivity. These data also suggest caution when interpreting relative stimulus-evoked functional MRI changes in diseased states where basal parameters are significantly perturbed. Quantitative blood flow MRI may serve as a valuable tool to study the retina without depth limitation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.