ArticleApplied and environmental microbiology2008
Loss of gibberellin production in Fusarium verticillioides (Gibberella fujikuroi MP-A) is due to a deletion in the gibberellic acid gene cluster.
Article in Applied and environmental microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- Assessment of Genetic Diversity and the Population Structure of Species from theJournal of fungi (Basel, Switzerland) · 2024Article
- A Genome-Wide Association Study To Understand the Effect ofG3 (Bethesda, Md.) · 2020Article
- The Gibberellin ProducerFrontiers in bioengineering and biotechnology · 2020Review
- A Genome Wide Association Study Reveals Markers and Genes Associated with Resistance toG3 (Bethesda, Md.) · 2019Article
- Multi-Homologous Recombination-Based Gene Manipulation in the Rice Pathogen Fusarium fujikuroi.The plant pathology journal · 2016Article
- Molecular and functional evolution of the fungal diterpene synthase genes.BMC microbiology · 2015Article
- Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.PLoS pathogens · 2013Article
- Identification and engineering of the cytochalasin gene cluster from Aspergillus clavatus NRRL 1.Metabolic engineering · 2011Article
- The Botrytis cinerea phytotoxin botcinic acid requires two polyketide synthases for production and has a redundant role in virulence with botrydial.Molecular plant pathology · 2011Article
- FfVel1 and FfLae1, components of a velvet-like complex in Fusarium fujikuroi, affect differentiation, secondary metabolism and virulence.Molecular microbiology · 2010Article
- Indole-diterpene biosynthetic capability of epichloë endophytes as predicted by ltm gene analysis.Applied and environmental microbiology · 2009Article
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
Fusarium verticillioides (Gibberella fujikuroi mating population A [MP-A]) is a widespread pathogen on maize and is well-known for producing fumonisins, mycotoxins that cause severe disease in animals and humans. The species is a member of the Gibberella fujikuroi species complex, which consists of at least 11 different biological species, termed MP-A to -K. All members of this species complex are known to produce a variety of secondary metabolites. The production of gibberellins (GAs), a group of diterpenoid plant hormones, is mainly restricted to Fusarium fujikuroi (G. fujikuroi MP-C) and Fusarium konzum (MP-I), although most members of the G. fujikuroi species complex contain the GA biosynthesis gene cluster or parts of it. In this work, we show that the inability to produce GAs in F. verticillioides (MP-A) is due to the loss of a majority of the GA gene cluster as found in F. fujikuroi. The remaining part of the cluster consists of the full-length F. verticillioides des gene (Fvdes), encoding the GA(4) desaturase, and the coding region of FvP450-4, encoding the ent-kaurene oxidase. Both genes share a high degree of sequence identity with the corresponding genes of F. fujikuroi. The GA production capacity of F. verticillioides was restored by transforming a cosmid with the entire GA gene cluster from F. fujikuroi, indicating the existence of an active regulation system in F. verticillioides. Furthermore, the GA(4) desaturase gene des from F. verticillioides encodes an active enzyme which was able to restore the GA production in a corresponding des deletion mutant of F. fujikuroi.
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