ArticleHuman molecular genetics2009
Common variants in the JAZF1 gene associated with height identified by linkage and genome-wide association analysis.
Article in Human molecular genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 6 of them syntheses that pooled it.
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Who cites it
60 citing papers in PubMed, 6 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- Genome-Wide Meta-Analysis Identifies Multiple Novel Rare Variants to Predict Common Human Infectious Diseases Risk.International journal of molecular sciences · 2023Pooled it
- Taller height as a risk factor for venous thromboembolism: a Mendelian randomization meta-analysis.Journal of thrombosis and haemostasis : JTH · 2017Pooled it
- A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.Human molecular genetics · 2013Pooled it
- Genome-wide association study in Han Chinese identifies three novel loci for human height.Human genetics · 2013Pooled it
- Genetic variation in GPR133 is associated with height: genome wide association study in the self-contained population of Sorbs.Human molecular genetics · 2009Pooled it
- Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.PLoS genetics · 2009Pooled it
- Polygenic risk score with KLK3 SNP-SNP interaction pairs for predicting prostate cancer aggressiveness.Communications medicine · 2026Article
- Analysis of 206 whole-genome resequencing reveals selection signatures associated with breed-specific traits in Hu sheep.Evolutionary applications · 2024Article
- Deletion ofProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Genomic Scan for Selection Signature Reveals Fat Deposition in Chinese Indigenous Sheep with Extreme Tail Types.Animals : an open access journal from MDPI · 2020Article
- Analysis of the genetic basis of height in large Jewish nuclear families.PLoS genetics · 2019Article
- Genetic variants at the 16p13 locus confer risk for eosinophilic esophagitis.Genes and immunity · 2019Article
- The DNA-polymorphism rs849142 is associated with skin toxicity induced by targeted anti-EGFR therapy using cetuximab.Oncotarget · 2018Article
- Systemic and specific effects of antihypertensive and lipid-lowering medication on plasma protein biomarkers for cardiovascular diseases.Scientific reports · 2018Article
- SweGen: a whole-genome data resource of genetic variability in a cross-section of the Swedish population.European journal of human genetics : EJHG · 2017Article
- Tea and coffee consumption in relation to DNA methylation in four European cohorts.Human molecular genetics · 2017Article
- National human genome projects: an update and an agenda.Epidemiology and health · 2017Article
- Genome-wide DNA methylation study identifies genes associated with the cardiovascular biomarker GDF-15.Human molecular genetics · 2016Article
- Breast cancer risk and genetic ancestry: a case-control study in Uruguay.BMC women's health · 2015Article
- Whole-exome imputation of sequence variants identified two novel alleles associated with adult body height in African Americans.Human molecular genetics · 2014Article
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Authors and funding
36 authors at 13 institutions in 9 countries.
Funding
Abstract
Genes for height have gained interest for decades, but only recently have candidate genes started to be identified. We have performed linkage analysis and genome-wide association for height in approximately 4000 individuals from five European populations. A total of five chromosomal regions showed suggestive linkage and in one of these regions, two SNPs (rs849140 and rs1635852) were associated with height (nominal P = 7.0 x 10(-8) and P = 9.6 x 10(-7), respectively). In total, five SNPs across the genome showed an association with height that reached the threshold of genome-wide significance (nominal P < 1.6 x 10(-7)). The association with height was replicated for two SNPs (rs1635852 and rs849140) using three independent studies (n = 31 077, n=1268 and n = 5746) with overall meta P-values of 9.4 x 10(-10) and 5.3 x 10(-8). These SNPs are located in the JAZF1 gene, which has recently been associated with type II diabetes, prostate and endometrial cancer. JAZF1 is a transcriptional repressor of NR2C2, which results in low IGF1 serum concentrations, perinatal and early postnatal hypoglycemia and growth retardation when knocked out in mice. Both the linkage and association analyses independently identified the JAZF1 region affecting human height. We have demonstrated, through replication in additional independent populations, the consistency of the effect of the JAZF1 SNPs on height. Since this gene also has a key function in the metabolism of growth, JAZF1 represents one of the strongest candidates influencing human height identified so far.
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