ArticleBiophysical journal2008
A quantitative model of cortical spreading depression due to purinergic and gap-junction transmission in astrocyte networks.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 51 citations in OpenAlex.
- Mathematical Psychiatry: On Cortical Spreading Depression-A Review.Brain sciences · 2023Review
- Analysis of Network Models with Neuron-Astrocyte Interactions.Neuroinformatics · 2023Article
- Hydrogen, Bicarbonate, and Their Associated Exchangers in Cell Volume Regulation.Frontiers in cell and developmental biology · 2021Article
- A computational study on the role of glutamate and NMDA receptors on cortical spreading depression using a multidomain electrodiffusion model.PLoS computational biology · 2019Article
- Electromechanics and Volume Dynamics in Nonexcitable Tissue Cells.Biophysical journal · 2018Article
- A mathematical model of recurrent spreading depolarizations.Journal of computational neuroscience · 2018Article
- The role of astrocytic calcium and TRPV4 channels in neurovascular coupling.Journal of computational neuroscience · 2018Article
- Neuroprotective Role of Gap Junctions in a Neuron Astrocyte Network Model.Biophysical journal · 2016Article
- Flow-Driven Cell Migration under External Electric Fields.Physical review letters · 2015Article
- Dynamics from seconds to hours in Hodgkin-Huxley model with time-dependent ion concentrations and buffer reservoirs.PLoS computational biology · 2014Article
- Cortical spreading depression and mitochondrial dysfunction with aging: lessons from ethanol abuse.Frontiers in aging neuroscience · 2014Article
- Mast cell-nerve cell interaction at acupoint: modeling mechanotransduction pathway induced by acupuncture.International journal of biological sciences · 2014Article
- Refractory period modulates the spatiotemporal evolution of cortical spreading depression: a computational study.PloS one · 2014Article
- A positive feedback cell signaling nucleation model of astrocyte dynamics.Frontiers in neuroengineering · 2013Article
- A mathematical model of the metabolic and perfusion effects on cortical spreading depression.PloS one · 2013Article
- Astrocyte regulation of sleep circuits: experimental and modeling perspectives.Frontiers in computational neuroscience · 2012Article
- Computational quest for understanding the role of astrocyte signaling in synaptic transmission and plasticity.Frontiers in computational neuroscience · 2012Article
- Article
- Spatiotemporal characteristics of calcium dynamics in astrocytes.Chaos (Woodbury, N.Y.) · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spreading depression (SD), a propagating wave of electrical silence in the cortex and archicortex, involves depolarization of neurons and astrocytes for approximately 1 min, due principally to a large increase in extracellular K+. SD is accompanied by large increases in extracellular ATP and is blocked by glutamate N-methyl-D-aspartate receptor antagonists. As a principal means of transmission between astrocytes is through their release of ATP, we have investigated if a model in which SD is driven by the effects of astrocyte waves of ATP interacting with waves of glutamate release from neurons and astrocytes can give a quantitative account of experimental observations on SD. We show that the characteristics of SD and the accompanying extracellular ionic changes can be accommodated by such a model-whether astrocyte transmission is principally through the release of ATP, as in archicortex (hippocampus) and spinal cord, or via gap junctions, as in the neocortex. Furthermore, these models give quantitative accounts of the effects on the characteristics of SD of agents toxic for astrocytes and of gap-junction blockers. Finally, an additional series of critical tests of the model is suggested.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.