ArticleThe Plant cell2008
NIP6;1 is a boric acid channel for preferential transport of boron to growing shoot tissues in Arabidopsis.
Article in The Plant cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.
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99 citing papers in PubMed, 315 citations in OpenAlex.
- Arabidopsis thaliana exhibits wide within-species variation in tolerance to boron limitation and root and shoot trait resilience associate with a pleiotropic locus.The New phytologist · 2025Article
- Genome-wide identification of boron transporters (GhBORs) in upland cotton and the role of GhBOR1 in promoting flowering.BMC plant biology · 2025Article
- The polar-localized borate exporter BOR1 facilitates boron transport in tapetal cells to the developing pollen grains.Plant physiology · 2025Article
- Transcriptional Analysis Reveals the Differences in Response of Floral Buds to Boron Deficiency Between Two ContrastingPlants (Basel, Switzerland) · 2025Article
- Global transcriptional modulation and nutritional status of soybean plants following foliar application of zinc borate as a suspension concentrate fertilizer.Scientific reports · 2025Article
- The AP2/ERF Transcription Factor ERF56 Negatively Regulating Nitrate-Dependent Plant Growth inInternational journal of molecular sciences · 2025Article
- Transport and regulatory mechanisms of boron in plants.Frontiers in plant science · 2025Review
- Arabidopsis KNS3 and its two homologs mediate endoplasmic reticulum-to-plasma membrane traffic of boric acid channels.Journal of experimental botany · 2024Article
- Integrative analysis of the transcriptome and proteome reveals the molecular responses of tobacco to boron deficiency.BMC plant biology · 2024Article
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- Physiological and molecular bases of the boron deficiency response in tomatoes.Horticulture research · 2023Article
- Analysis ofPlants (Basel, Switzerland) · 2023Article
- Genome-Wide Analysis of Aquaporins in Japanese Morning Glory (Plants (Basel, Switzerland) · 2023Article
- What Can Boron Deficiency Symptoms Tell Us about Its Function and Regulation?Plants (Basel, Switzerland) · 2023Review
- Review
- The structure, function and expression analysis of the nodulin 26-like intrinsic protein subfamily of plant aquaporins in tomato.Scientific reports · 2022Article
- Tea plant roots respond to aluminum-induced mineral nutrient imbalances by transcriptional regulation of multiple cation and anion transporters.BMC plant biology · 2022Article
- Metalloid transporters and their regulation in plants.Plant physiology · 2021Review
- Three regions of thePlant signaling & behavior · 2021Article
- Integrated ionomic and transcriptomic dissection reveals the core transporter genes responsive to varying cadmium abundances in allotetraploid rapeseed.BMC plant biology · 2021Article
39 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Boron (B) in soil is taken up by roots through NIP5;1, a boric acid channel, and is loaded into the xylem by BOR1, a borate exporter. Here, the function of Arabidopsis thaliana NIP6;1, the most similar gene to NIP5;1, was studied. NIP6;1 facilitates the rapid permeation of boric acid across the membrane but is completely impermeable to water. NIP6;1 transcript accumulation is elevated in response to B deprivation in shoots but not in roots. NIP6;1 promoter-beta-glucuronidase is predominantly expressed in nodal regions of shoots, especially the phloem region of vascular tissues. Three independently identified T-DNA insertion lines for the NIP6;1 gene exhibited reduced expansion of young rosette leaves only under low-B conditions. B concentrations are reduced in young rosette leaves but not in the old leaves of these mutants. Taken together, these data strongly suggest that NIP6;1 is a boric acid channel required for proper distribution of boric acid, particularly among young developing shoot tissues. We propose that NIP6;1 is involved in xylem-phloem transfer of boric acid at the nodal regions and that the water-tight property of NIP6;1 is important for this function. It is proposed that during evolution, NIP5;1 and NIP6;1 were diversified in terms of both the specificity of their expression in plant tissues and their water permeation properties, while maintaining their ability to be induced under low B and their boric acid transport activities.
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