Evidence map›Paper›PMID 18952199›Full record

ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2009

Controversies in ulcerative colitis: a survey comparing decision making of experts versus community gastroenterologists.

Brennan M R Spiegel, Wayne Ho, Eric Esrailian, Stephan Targan, Peter D R Higgins, Corey A Siegel, Marla Dubinsky, Gil Y Melmed

Abstract readComparative Study
In one paragraph

Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 60 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Brennan M R SpiegelVeteran's Administration Greater Los Angeles Healthcare System, Los Angeles, California, USA. bspiegel@mednet.ulca.edu
Wayne Ho
Eric Esrailian
Stephan Targan
Peter D R Higgins
Corey A Siegel
Marla Dubinsky
Gil Y Melmed
Cedars-Sinai Medical Center · USVA Greater Los Angeles Healthcare System · USDartmouth–Hitchcock Medical Center · USUniversity of California, Los Angeles · USUniversity of Michigan–Ann Arbor · US

Funding

Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0M
Development and Initial Validation of PROMIS GI Distress ScaleU01AR057936 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KHANNA, DINESH, SPIEGEL, BRENNAN · 2009 to 2013
$2.2M
Risk Communication in Crohn's DiseaseK23DK078678 · NIDDK · DARTMOUTH COLLEGE · PI SIEGEL, COREY · 2008 to 2012
$796k
NIAMS NIH HHS U01 AR057936NIDDK NIH HHS 1K23DK078678-01A1NIDDK NIH HHS 2P30 DK 041301-17NIDDK NIH HHS K23 DK078678NIDDK NIH HHS P30 DK041301
6 · The paper itself

Abstract

BACKGROUND &

aimsDespite the development of consensus guidelines in ulcerative colitis (UC), there remain several areas of uncertainty in the everyday management of this incompletely understood disease. We performed a national vignette survey to measure variations in decision-making in areas of controversy.

methodsWe constructed a survey with 3 vignettes to measure decision-making in 4 areas of controversy in UC: (1) dysplasia management, (2) mesalamine dosing, (3) diagnostic testing for underlying Crohn's disease, and (4) treatment of steroid-refractory inpatient UC. We compared responses between a group of community gastroenterologists and UC experts.

resultsWe received 192 responses (36% response). Compared with community gastroenterologists, UC experts were more likely to endorse colectomy for both unifocal and multifocal low-grade dysplasia, use narrow band imaging and chromoendoscopy for surveillance colonoscopy, use high-dose mesalamine for inducing remission, use long-term mesalamine for cancer chemoprevention, order computed tomography enterography to evaluate for Crohn's disease, and to have a lower threshold to call for surgery consultation in steroid-refractory UC. There was little agreement regarding the optimal frequency of surveillance colonoscopy, even among experts. Most respondents favored using infliximab over cyclosporine in steroid-refractory UC.

conclusionsCommunity gastroenterologists and UC experts vary dramatically in their approach to many areas of uncertainty in UC. The only area of consensus between groups is the use of infliximab over cyclosporine in steroid-refractory UC, itself a controversial decision. These data suggest that current practice patterns are highly disparate and focus attention on specific areas of disconnect that should be further investigated.

Indexed as

Decision MakingAdultColitis, UlcerativeCrohn DiseaseData CollectionDiagnostic Tests, RoutineFemaleHealth Services ResearchHumansImmunosuppressive AgentsMaleMiddle AgedPractice Patterns, Physicians'Surveys and QuestionnairesImmunosuppressive Agents

Identifiers

PMID18952199
PMCPMC3804428
OpenAlexW2163535452

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.